ISDA: 9CR7

Deposition Date 2024-07-20

Release Date 2025-07-30

Last Version Date 2025-07-30

Entry Detail

PDB ID:

9CR7

Keywords:

TRANSFERASE/TRANSFERASE INHIBITOR

Title:

Structure of human SETD8 in complex with covalent inhibitor AM2928

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.05 Å

R-Value Free:

0.23

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:N-lysine methyltransferase KM
Gene (Uniprot):KMT5A
Chain IDs:A, B
Chain Length:176
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q9NQR1 Pfam ID:PF00856 EC:2.1.1.361

Ligand Molecules

E1J

H81

Primary Citation

Structure-Activity relationship studies of SETD8 covalent inhibitors

Ma, A, Babault, N, Hong, W, Dong, A, Hong, Z, Xin, C, Park, K.S, Brown, P.J, Liu, J, Vedadi, M, Jin, J.Show

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