ISDA: 9BRO

Deposition Date 2024-05-11

Release Date 2025-11-12

Last Version Date 2025-11-12

Entry Detail

PDB ID:

9BRO

Keywords:

SIGNALING PROTEIN/INHIBITOR

Title:

Crystal Structure of Human G Protein-Coupled Receptor Kinase 5 in Complex with GRL030-22

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.80 Å

R-Value Free:

0.27

R-Value Work:

0.21

R-Value Observed:

0.22

Space Group:

P 41 21 2

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:G protein-coupled receptor ki
Gene (Uniprot):GRK5
Chain IDs:A
Chain Length:598
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P34947 Pfam ID:PF00615, PF00069 EC:2.7.11.16

Ligand Molecules

A1ARE

Primary Citation

Structure of GRK5 in complex with novel inhibitors

Chen, Y, Tesmer, J.J.G.Show

To be published ? ? ? (?)

Primary Citation of related structures

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