ISDA: 9B4Y

Deposition Date 2024-03-21

Release Date 2025-03-26

Last Version Date 2026-04-08

Entry Detail

PDB ID:

9B4Y

Keywords:

TRANSPORT PROTEIN

Title:

Cryo-EM structure of importin alpha-1/beta bound to TDP-43

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.74 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Importin subunit beta-1
Gene (Uniprot):KPNB1
Chain IDs:A
Chain Length:876
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q14974 Pfam ID:PF03810, PF00514, PF25574

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Importin subunit alpha-1
Gene (Uniprot):KPNA2
Chain IDs:B
Chain Length:43
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P52292 Pfam ID:PF01749

Ligand Molecules

Primary Citation

Single Acetylation-mimetic Mutation in TDP-43 Nuclear Localization Signal Disrupts Importin alpha 1/ beta Signaling.

Ko, Y.H, Lokareddy, R.K, Doll, S.G, Yeggoni, D.P, Girdhar, A, Mawn, I, Klim, J.R, Rizvi, N.F, Meyers, R, Gillilan, R.E, Guo, L, Cingolani, G.Show

J. Mol. Biol. 436 168751 168751 (2024)

PMID: 39181183 DOI: 10.1016/j.jmb.2024.168751

Primary Citation of related structures

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