9AXV image
Deposition Date 2024-03-06
Release Date 2024-10-16
Last Version Date 2024-10-23
Entry Detail
PDB ID:
9AXV
Keywords:
RIBOSOME
Title:
Translating S. pombe ribosome
Biological Source:
Source Organism(s):
Schizosaccharomyces pombe (Taxon ID: 4896)
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.40 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
9AXV validation report missing
Macromolecular Entities
Polymer Type:polyribonucleotide
Molecule:18S ribosomal RNA
Chain IDs:A (auth: AA)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps001
Chain IDs:B (auth: AD)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:Q9Y7L8 Pfam ID:PF00318, PF16122
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps102
Chain IDs:C (auth: AE)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:O94438 Pfam ID:PF01015
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps2
Chain IDs:D (auth: AF)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:O74892 Pfam ID:PF00333, PF03719
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps3
Chain IDs:E (auth: AG)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:O60128 Pfam ID:PF07650, PF00189
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps403
Chain IDs:F (auth: AH)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:Q9P4W9 Pfam ID:PF08071, PF00900, PF00467, PF16121
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps5
Chain IDs:G (auth: AI)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:O14277 Pfam ID:PF00177
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps602
Chain IDs:H (auth: AJ)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:Q9C0Z7 Pfam ID:PF01092
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps7
Chain IDs:I (auth: AK)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:Q10101 Pfam ID:PF01251
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps802
Chain IDs:J (auth: AL)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:Q9P7B2 Pfam ID:PF01201
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps902
Chain IDs:K (auth: AM)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:O59675 Pfam ID:PF00163, PF01479
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps1002
Chain IDs:L (auth: AN)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:O13614 Pfam ID:PF03501
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps1101
Chain IDs:M (auth: AO)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:P0CT73 Pfam ID:PF16205, PF00366
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps1201
Chain IDs:N (auth: AP)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:O14062 Pfam ID:PF01248
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps13
Chain IDs:O (auth: AQ)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:P28189 Pfam ID:PF08069, PF00312
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps1402
Chain IDs:P (auth: AR)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:P0CT57 Pfam ID:PF00411
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps1502
Chain IDs:Q (auth: AS)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:Q9UTQ6 Pfam ID:PF00203
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps1601
Chain IDs:R (auth: AT)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:P0CT64 Pfam ID:PF00380
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps1701
Chain IDs:S (auth: AU)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:O42984 Pfam ID:PF00833
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps1802
Chain IDs:T (auth: AV)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:P0CT67 Pfam ID:PF00416
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps1901
Chain IDs:U (auth: AW)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:P58234 Pfam ID:PF01090
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps20
Chain IDs:V (auth: Aa)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:O74893 Pfam ID:PF00338
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps21
Chain IDs:W (auth: Ab)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:P05764 Pfam ID:PF01249
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps2201
Chain IDs:X (auth: Ac)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:P0CT58 Pfam ID:PF00410
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps23
Chain IDs:Y (auth: Ad)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:P0CT75 Pfam ID:PF00164
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps2401
Chain IDs:Z (auth: Ae)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:O13784 Pfam ID:PF01282
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps2502
Chain IDs:AA (auth: Af)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:P79009 Pfam ID:PF03297
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps2602
Chain IDs:BA (auth: Ag)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:Q9UTG4 Pfam ID:PF01283
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps27
Chain IDs:CA (auth: Ah)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:O74330 Pfam ID:PF01667
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps2801
Chain IDs:DA (auth: Ai)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:P0CT79 Pfam ID:PF01200
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps29
Chain IDs:EA (auth: Aj)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:O74329 Pfam ID:PF00253
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):rps3002
Chain IDs:FA (auth: Ak)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:P0CT63 Pfam ID:PF04758
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):cpc2
Chain IDs:XB (auth: Am)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:Q10281 Pfam ID:PF00400
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl42
Chain IDs:GA (auth: B0)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:Q9UTI8 Pfam ID:PF00935
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl4301
Chain IDs:HA (auth: B1)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:Q9HGL8 Pfam ID:PF01780
Polymer Type:polyribonucleotide
Molecule:28S ribosomal RNA
Chain IDs:IA (auth: B2)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polyribonucleotide
Molecule:5S ribosomal RNA
Chain IDs:JA (auth: B3)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polyribonucleotide
Molecule:5.8S ribosomal RNA
Chain IDs:KA (auth: B4)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl803
Chain IDs:LA (auth: BN)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:P0CT72 Pfam ID:PF00181, PF03947
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl301
Chain IDs:MA (auth: BO)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:P40372 Pfam ID:PF00297
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl402
Chain IDs:NA (auth: BP)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:P35679 Pfam ID:PF00573, PF14374
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl502
Chain IDs:OA (auth: BQ)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:O74306 Pfam ID:PF17144, PF14204
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl6
Chain IDs:PA (auth: BR)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:P79071 Pfam ID:PF01159
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl701
Chain IDs:QA (auth: BS)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:O60143 Pfam ID:PF08079, PF00327
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl8
Chain IDs:RA (auth: BT)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:O13672 Pfam ID:PF01248
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl902
Chain IDs:SA (auth: BU)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:O74905 Pfam ID:PF00347
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl1001
Chain IDs:TA (auth: BV)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:Q09127 Pfam ID:PF00252
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl1101
Chain IDs:UA (auth: BW)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:P0CT77 Pfam ID:PF00281, PF00673
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl13
Chain IDs:VA (auth: BX)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:O74175 Pfam ID:PF01294
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl14
Chain IDs:WA (auth: BY)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:O94238 Pfam ID:PF00467, PF01929
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl1502
Chain IDs:XA (auth: BZ)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:Q9US22 Pfam ID:PF00827
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl1602
Chain IDs:YA (auth: Ba)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:O42848 Pfam ID:PF00572
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl1701
Chain IDs:ZA (auth: Bb)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:O14339 Pfam ID:PF00237
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl1802
Chain IDs:AB (auth: Bc)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:Q8TFH1 Pfam ID:PF17135
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl1902
Chain IDs:BB (auth: Bd)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:O42699 Pfam ID:PF01280, PF25476
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl2001
Chain IDs:CB (auth: Be)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:P0CT68 Pfam ID:PF01775
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl2102
Chain IDs:DB (auth: Bf)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:O42706 Pfam ID:PF01157
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl22
Chain IDs:EB (auth: Bg)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:Q09668 Pfam ID:PF01776
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl2302
Chain IDs:FB (auth: Bh)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:P0CT61 Pfam ID:PF00238
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl2402
Chain IDs:GB (auth: Bi)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:O74884 Pfam ID:PF01246
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl2501
Chain IDs:HB (auth: Bj)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:Q10330 Pfam ID:PF03939, PF00276
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl26
Chain IDs:IB (auth: Bk)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:P78946 Pfam ID:PF16906, PF00467
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl2701
Chain IDs:JB (auth: Bl)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:O14388 Pfam ID:PF00467, PF01777
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl2801
Chain IDs:KB (auth: Bm)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:P57728 Pfam ID:PF00828
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl29
Chain IDs:LB (auth: Bn)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:Q92366 Pfam ID:PF01779
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl3001
Chain IDs:MB (auth: Bo)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:P52808 Pfam ID:PF01248
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl31
Chain IDs:NB (auth: Bp)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:Q9URX6 Pfam ID:PF01198
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl3202
Chain IDs:OB (auth: Bq)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:P79015 Pfam ID:PF01655
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl35b
Chain IDs:PB (auth: Br)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:Q9USX4 Pfam ID:PF01247
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl3402
Chain IDs:QB (auth: Bs)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:Q9URT8 Pfam ID:PF01199
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl35
Chain IDs:RB (auth: Bt)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:O74904 Pfam ID:PF00831
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl3602
Chain IDs:SB (auth: Bu)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:O94658 Pfam ID:PF01158
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl3702
Chain IDs:TB (auth: Bv)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:P05733 Pfam ID:PF01907
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl3801
Chain IDs:UB (auth: Bw)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:Q9USR7 Pfam ID:PF01781
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl39
Chain IDs:VB (auth: Bx)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:P05767 Pfam ID:PF00832
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):rpl44
Chain IDs:WB (auth: By)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
UniProt ID:O14069 Pfam ID:PF01778
Polymer Type:polyribonucleotide
Molecule:mRNA
Chain IDs:AC (auth: S3)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polyribonucleotide
Molecule:tRNA
Chain IDs:YB (auth: Sm)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Polymer Type:polyribonucleotide
Molecule:A/P tRNA
Chain IDs:ZB (auth: Sn)
Chain Length:0
Number of Molecules:1
Biological Source:Schizosaccharomyces pombe
Ligand Molecules
ZN
Primary Citation
Ribosomes hibernate on mitochondria during cellular stress.
Nat Commun 15 8666 8666 (2024)
PMID: 39379376 DOI: 10.1038/s41467-024-52911-4

Abstact

Cell survival under nutrient-deprived conditions relies on cells' ability to adapt their organelles and rewire their metabolic pathways. In yeast, glucose depletion induces a stress response mediated by mitochondrial fragmentation and sequestration of cytosolic ribosomes on mitochondria. This cellular adaptation promotes survival under harsh environmental conditions; however, the underlying mechanism of this response remains unknown. Here, we demonstrate that upon glucose depletion protein synthesis is halted. Cryo-electron microscopy structure of the ribosomes show that they are devoid of both tRNA and mRNA, and a subset of the particles depicted a conformational change in rRNA H69 that could prevent tRNA binding. Our in situ structural analyses reveal that the hibernating ribosomes tether to fragmented mitochondria and establish eukaryotic-specific, higher-order storage structures by assembling into oligomeric arrays on the mitochondrial surface. Notably, we show that hibernating ribosomes exclusively bind to the outer mitochondrial membrane via the small ribosomal subunit during cellular stress. We identify the ribosomal protein Cpc2/RACK1 as the molecule mediating ribosomal tethering to mitochondria. This study unveils the molecular mechanism connecting mitochondrial stress with the shutdown of protein synthesis and broadens our understanding of cellular responses to nutrient scarcity and cell quiescence.

Legend

Protein

Chemical

Disease

Primary Citation of related structures
9AXT
9AXU
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