ISDA: 9AVM

Deposition Date 2024-03-04

Release Date 2025-03-12

Last Version Date 2026-04-29

Entry Detail

PDB ID:

9AVM

Keywords:

IMMUNE SYSTEM

Title:

Crystal Structure of CARD9 coiled-coil K156-K214

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.79 Å

R-Value Free:

0.29

R-Value Work:

0.24

R-Value Observed:

0.24

Space Group:

P 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Caspase recruitment domain-co
Gene (Uniprot):CARD9
Chain IDs:A, B, C, D
Chain Length:60
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:Q9H257

Primary Citation

Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity.

Rush, J.S, Wertheimer, J.D, Goldberg, S.D, Raymond, D, Szuchnicki, M, Baltus, A.J, Branson, J, Stratton, C.F, Patrick, A.N, Steele, R, Adhikary, S, Del Rosario, A, Liu, A, Gomersall, N.J, Chung, M, Ranaghan, M.J, Gu, X, Brandt, M, Cao, Z, Bebenek, A, Oliver, B.A, Hoebe, K, Szewczuk, L.M, Venable, J.D, Graham, D.B, Towne, J, Xavier, R.J.Show

Cell 189 1356 1370.e26 (2026)

PMID: 41547356 DOI: 10.1016/j.cell.2025.12.013

Primary Citation of related structures

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