ISDA: 8ZQE

Deposition Date 2024-06-02

Release Date 2024-07-10

Last Version Date 2024-11-27

Entry Detail

PDB ID:

8ZQE

Keywords:

MEMBRANE PROTEIN

Title:

Cryo-EM structure of the GPR15L(C11)-bound GPR15 complex

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.90 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNAI1
Chain IDs:A
Chain Length:354
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P63096 Pfam ID:PF00503

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:B
Chain Length:340
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62873 Pfam ID:PF00400, PF25391

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Chain IDs:C
Chain Length:97
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P59768 Pfam ID:PF00631

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Protein GPR15LG
Gene (Uniprot):GPR15LG
Chain IDs:F (auth: L)
Chain Length:10
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q6UWK7

Protein Blast

Polymer Type:polypeptide(L)
Molecule:GPR15
Chain IDs:E (auth: R)
Chain Length:881
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P0ABE7,P49685,P0AEX9 Pfam ID:PF07361, PF00001, PF01547

Protein Blast

Polymer Type:polypeptide(L)
Molecule:scFv16
Chain IDs:D (auth: S)
Chain Length:279
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

Primary Citation

Molecular recognition of the atypical chemokine-like peptide GPR15L by its cognate receptor GPR15.

Zhang, Z, Zheng, Y, Xu, L, Yue, Y, Xu, K, Li, F, Xu, F.Show

Cell Discov 10 69 69 (2024)

PMID: 38918398 DOI: 10.1038/s41421-024-00698-5

Primary Citation of related structures

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