ISDA: 8ZNN

Deposition Date 2024-05-27

Release Date 2025-12-24

Last Version Date 2026-07-08

Entry Detail

PDB ID:

8ZNN

Keywords:

NUCLEAR PROTEIN

Title:

X-ray structure of human PPAR delta ligand binding domain in complex with a synthetic agonist 16a

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.95 Å

R-Value Free:

0.22

R-Value Work:

0.19

Space Group:

P 2 21 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Peroxisome proliferator-activ
Gene (Uniprot):PPARD
Chain IDs:A
Chain Length:270
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q03181 Pfam ID:PF00104

Ligand Molecules

A1D86

Primary Citation

Design, Synthesis, and Biological Evaluation of Arylimidazole Derivatives as Potent PPAR delta Agonists for the Treatment of Renal Fibrosis.

Feng, Z, Xie, J, Hou, D, Fu, Z, Sun, S, Liu, X, Sun, G, Zheng, R, Liu, L, Xu, Q, Wen, X, Zhang, D, Yuan, H, Sun, H, Dai, L.Show

J.Med.Chem. 69 4469 4492 (2026)

PMID: 41667192 DOI: 10.1021/acs.jmedchem.5c03132

Primary Citation of related structures

Feedback Form