8Z8L image
Deposition Date 2024-04-22
Release Date 2025-04-30
Last Version Date 2026-05-13
Entry Detail
PDB ID:
8Z8L
Keywords:
CYTOKINE
Title:
structure of IL-4Ra in complex with an nanobody 4E9
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Vicugna pacos (Taxon ID: 30538)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
3.96 Å
R-Value Free:
0.33
R-Value Work:
0.30
R-Value Observed:
0.30
Space Group:
H 3 2
8Z8L validation report missing
Macromolecular Entities
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:nanobody dAb1
Chain IDs:B (auth: A)
Chain Length:124
Number of Molecules:1
Biological Source:Vicugna pacos
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Interleukin-4 receptor subuni
Gene (Uniprot):IL4R
Mutagens:C182A
Chain IDs:A (auth: B)
Chain Length:214
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P24394 Pfam ID:PF09238
Ligand Molecules
NAG
Primary Citation
Structural insight into interleukin-4R alpha and interleukin-5 inhibition by nanobodies from a bispecific antibody.
MedComm (2020) 5 e700 e700 (2024)
PMID: 39252822 DOI: 10.1002/mco2.700
Primary Citation of related structures
8Z8L
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