8YRQ image
Deposition Date 2024-03-21
Release Date 2026-06-10
Last Version Date 2026-06-10
Entry Detail
PDB ID:
8YRQ
Keywords:
MEMBRANE PROTEIN/IMMUNE SYSTEM
Title:
Cryo-EM Structure of Human Protease-Activated Receptor 4 in complex with Gq heterotrimers and ScFv16 bound to Tethered Ligand
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Escherichia coli K-12 (Taxon ID: 83333)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
2.80 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
8YRQ validation report missing
Macromolecular Entities
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Chain IDs:B (auth: A)
Chain Length:228
Number of Molecules:1
Biological Source:Homo sapiens
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:C (auth: B)
Chain Length:354
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P62873 Pfam ID:PF25391
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:D (auth: G)
Chain Length:81
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P59768 Pfam ID:PF00631
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Proteinase-activated receptor
Gene (Uniprot):malE, F2RL3
Chain IDs:A (auth: R)
Chain Length:714
Number of Molecules:1
Biological Source:Homo sapiens, Escherichia coli K-12
UniProt ID:Q96RI0,P0AEX9 Pfam ID:PF00001, PF01547 EC:7.5.2.1
Protein Blast
Polymer Type:polypeptide(L)
Molecule:ScFv16
Chain IDs:E (auth: S)
Chain Length:303
Number of Molecules:1
Biological Source:Homo sapiens
Ligand Molecules
NA
Primary Citation
Cryo-EM Structure of Human Protease-Activated Receptor 4 in complex with Gq heterotrimers bound to Tethered Ligand
To Be Published ? ? ? (?)
Primary Citation of related structures
8YRQ
Feedback Form
Name
Email
Institute
Feedback