ISDA: 8YD4

Deposition Date 2024-02-19

Release Date 2025-02-12

Last Version Date 2026-04-01

Entry Detail

PDB ID:

8YD4

Keywords:

HYDROLASE

Title:

CryoEM structure of apo M. tuberculosis ClpP1P2

Biological Source:

Source Organism(s):

Mycobacterium tuberculosis H37Rv (Taxon ID: 83332)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.69 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:ATP-dependent Clp protease pr
Gene (Uniprot):clpP1
Chain IDs:A, B, C, D, E, F, G
Chain Length:200
Number of Molecules:7
Biological Source:Mycobacterium tuberculosis H37Rv

UniProt ID:P9WPC5 Pfam ID:PF00574 EC:3.4.21.92

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:ATP-dependent Clp protease pr
Gene (Uniprot):clpP2
Chain IDs:H, I, J, K, L, M, N
Chain Length:214
Number of Molecules:7
Biological Source:Mycobacterium tuberculosis H37Rv

UniProt ID:P9WPC3 Pfam ID:PF00574 EC:3.4.21.92

Ligand Molecules

Primary Citation

Structural Insights into Bortezomib-Induced Activation of the Caseinolytic Chaperone-Protease System in Mycobacterium tuberculosis

Zhou, B, Gao, Y, Zhao, H, Liu, B, Zhang, H, Fang, C, Yuan, H, Wang, J, Li, Z, Zhao, Y, Huang, X, Wang, X, Oliveira, A.S.F, Spencer, J, Mulholland, A.J, Burston, S.G, Hu, J, Su, N, Chen, X, He, J, Zhang, T, Xiong, X.Show

Nat Commun 16 3466 ? (2025)

DOI: 10.1038/s41467-025-58410-4

Primary Citation of related structures

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