ISDA: 8XVN

Deposition Date 2024-01-15

Release Date 2025-01-15

Last Version Date 2026-07-29

Entry Detail

PDB ID:

8XVN

Keywords:

OXIDOREDUCTASE

Title:

Short-chain dehydrogenase/reductase6 (SDR6) from Antrodia camphorata

Biological Source:

Source Organism(s):

Taiwanofungus camphoratus (Taxon ID: 2696576)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.00 Å

R-Value Free:

0.19

R-Value Work:

0.16

R-Value Observed:

0.16

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Short-chain dehydrogenases/re
Chain IDs:A, B, C, D, E, F, G, H
Chain Length:270
Number of Molecules:8
Biological Source:Taiwanofungus camphoratus

UniProt ID:A0A165BBH9 Pfam ID:PF00106

Primary Citation

[Not Available].

Zhang, Y.Q, Zhang, M, Wang, Z.L, Bao, Y.O, Wang, Y.Q, Tian, Y.G, Ye, L, Ye, M.Show

Angew.Chem.Int.Ed.Engl. 64 e202420104 e202420104 (2025)

PMID: 39617723 DOI: 10.1002/anie.202420104

Abstact

Through different gene mining strategies, three key enzymes (AcCYP4, AcSDR6, AcSMT1) involved in the downstream biosynthesis of major lanostane-type triterpenoids were discovered and identified from Antrodia camphorata. The catalytic mechanisms of AcSDR6 were elucidated by crystal structure analysis. These post-modification enzymes could be used to synthesize at least 11 major Antrodia lanostanoids.

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Primary Citation of related structures

Abstact

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