8XQ0 image
Deposition Date 2024-01-04
Release Date 2025-01-15
Last Version Date 2025-01-15
Entry Detail
PDB ID:
8XQ0
Keywords:
SIGNALING PROTEIN/INHIBITOR
Title:
Crystal structure of spleen tyrosine kinase(SYK)in complex with SKI-G-1653
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Spodoptera frugiperda
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.95 Å
R-Value Free:
0.26
R-Value Work:
0.21
R-Value Observed:
0.22
Space Group:
P 1
8XQ0 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Tyrosine-protein kinase SYK
Gene (Uniprot):SYK
Chain IDs:A, B, C, D
Chain Length:290
Number of Molecules:4
Biological Source:Homo sapiens
UniProt ID:P43405 Pfam ID:PF07714 EC:2.7.10.2
Ligand Molecules
A1LV4
Primary Citation
Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix
Acta Crystallogr., Sect. D: Biol. Crystallogr. 75 861 877 (2019)
Primary Citation of related structures
8XQ0
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