ISDA: 8X4N

Deposition Date 2023-11-15

Release Date 2025-02-19

Last Version Date 2026-04-08

Entry Detail

PDB ID:

8X4N

Keywords:

TRANSFERASE

Title:

Crystal structure of the PI3P-binding domain of Legionella SetA in complex with inositol 1,3-bisphosphate

Biological Source:

Source Organism(s):

Legionella pneumophila (Taxon ID: 446)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.46 Å

R-Value Free:

0.25

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

C 1 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Subversion of eukaryotic traf
Gene (Uniprot):setA
Chain IDs:A, B
Chain Length:126
Number of Molecules:2
Biological Source:Legionella pneumophila

UniProt ID:Q5ZU30

Ligand Molecules

GOL

ITP

Primary Citation

Structural insights into SetA-mediated Rab1 glucosylation and PI3P-guided localization during early Legionella infection.

Im, H.N, Lee, Y, Song, Y, Hahn, H, Jeon, H, Shin, D, Lee, S, Kim, K.H, Kim, K.T, Suh, S.W, Jang, D.M, Kim, H.S.Show

Proc.Natl.Acad.Sci.USA 123 e2535016123 e2535016123 (2026)

PMID: 41894332 DOI: 10.1073/pnas.2535016123

Primary Citation of related structures

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