ISDA: 8WZZ

Deposition Date 2023-11-02

Release Date 2024-11-06

Last Version Date 2025-05-21

Entry Detail

PDB ID:

8WZZ

Keywords:

OXIDOREDUCTASE

Title:

Short-chain dehydrogenase/reductase16 (SDR16) from Antrodia camphorata

Biological Source:

Source Organism(s):

Taiwanofungus camphoratus (Taxon ID: 2696576)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.95 Å

R-Value Free:

0.23

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:SDR16
Chain IDs:A
Chain Length:303
Number of Molecules:1
Biological Source:Taiwanofungus camphoratus

UniProt ID:A0A165FX75 Pfam ID:PF00248

Primary Citation

Identification of Key Post‐modification Enzymes Involved in the Biosynthesis of Lanostane‐type Triterpenoids in the Medicinal Mushroom Antrodia camphorata

Zhang, Y.Q, Zhang, M, Wang, Z.L, Bao, Y.O, Wang, Y.Q, Tian, Y.G, Ye, L, Ye, M.Show

Angew. Chem. Int. Ed. Engl. 64 e202420104 e202420104 (2025)

PMID: 39617723 DOI: 10.1002/anie.202420104

Abstact

Through different gene mining strategies, three key enzymes (AcCYP4, AcSDR6, AcSMT1) involved in the downstream biosynthesis of major lanostane-type triterpenoids were discovered and identified from Antrodia camphorata. The catalytic mechanisms of AcSDR6 were elucidated by crystal structure analysis. These post-modification enzymes could be used to synthesize at least 11 major Antrodia lanostanoids.

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Primary Citation of related structures

Abstact

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