ISDA: 8WWX

Deposition Date 2023-10-27

Release Date 2023-11-08

Last Version Date 2026-07-29

Entry Detail

PDB ID:

8WWX

Keywords:

LIGASE

Title:

Ube1L acts akin to a mitt, that mediates UbcH8 binding and orchestrates "E1-E2" interaction

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli m15

Method Details:

Experimental Method:

SOLUTION NMR

Conformers Calculated:

400

Conformers Submitted:

Selection Criteria:

structures with the lowest energy

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Ubiquitin-like modifier-activ
Gene (Uniprot):UBA7
Chain IDs:A
Chain Length:93
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P41226 Pfam ID:PF09358

Ligand Molecules

Primary Citation

Dynamic Hotspots in the Uba7 Ubiquitin-Fold Domain Direct UbcH8 Recognition.

Dag, C, Lambert, M, Kazar, A.E, Kahraman, K, Gocenler, O, Lee, W, Tozkoparan Ceylan, C.D, Lohr, F, Shim, J.G, Haas, A.L, Dotsch, V, Ziarek, J, Elgin, E.S.Show

Biochemistry 65 678 692 (2026)

PMID: 41773046 DOI: 10.1021/acs.biochem.5c00807

Primary Citation of related structures

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