8WEO image
Deposition Date 2023-09-18
Release Date 2024-09-25
Last Version Date 2026-04-08
Entry Detail
PDB ID:
8WEO
Keywords:
TOXIN/IMMUNE SYSTEM
Title:
Bacteroides fragilis toxin in complex with neutralization nanobody
Biological Source:
Source Organism(s):
Bacteroides fragilis (Taxon ID: 817)
Vicugna pacos (Taxon ID: 30538)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.50 Å
R-Value Free:
0.19
R-Value Work:
0.17
R-Value Observed:
0.17
Space Group:
P 65
8WEO validation report
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Fragilysin
Gene (Uniprot):btfP
Chain IDs:A (auth: B), C (auth: A)
Chain Length:186
Number of Molecules:2
Biological Source:Bacteroides fragilis
UniProt ID:P54355 Pfam ID:PF13688
Polymer Type:polypeptide(L)
Molecule:NB243
Chain IDs:B (auth: C), D
Chain Length:126
Number of Molecules:2
Biological Source:Vicugna pacos
Ligand Molecules
ZN
Primary Citation
Mechanistic diversity of Bacteroides fragilis toxins and neutralization with single domain antibody.
Cell Chem Biol 33 102 116.e6 (2026)
PMID: 41544614 DOI: 10.1016/j.chembiol.2025.12.009
Primary Citation of related structures
8WEO
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