ISDA: 8VZW

Deposition Date 2024-02-12

Release Date 2026-03-18

Last Version Date 2026-03-18

Entry Detail

PDB ID:

8VZW

Keywords:

IMMUNE SYSTEM

Title:

Structure of humanized MS-Hu6 Fab fragment

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.50 Å

R-Value Free:

0.25

R-Value Work:

0.22

R-Value Observed:

0.22

Space Group:

P 1 21 1

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:MS-Hu6 Fab Heavy Chain
Chain IDs:B (auth: H)
Chain Length:233
Number of Molecules:1
Biological Source:Homo sapiens

Polymer Type:polypeptide(L)
Molecule:MS-Hu6 Fab Light Chain
Chain IDs:A (auth: L)
Chain Length:214
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

SO4

Primary Citation

Efficacy and safety of a therapeutic humanized FSH-blocking antibody in obesity and Alzheimer's disease models.

Pallapati, A.R, Korkmaz, F, Rojekar, S, Sims, S, Misra, A, Gimenez-Roig, J, Gangadhar, A, Laurencin, V, Gumerova, A, Cheliadinova, U, Sultana, F, Vasilyeva, D, Cullen, L, Schuermann, J, Munitz, J, Kannangara, H, Parte, S, Pevnev, G, Burganova, G, Tumoglu, Z, Witztum, R, Wizman, S, Kramskiy, N, Igel, L, Sen, F, Ranzenigo, A, Macdonald, A, Hutchison, S, Teunissen, A.J, Burkart, H, Saxena, M, Ginsburg, Y, Goosens, K, Zhou, W, Ryu, V, Moldavski, O, Barak, O, Pazianas, M, Caminis, J, Bhasin, S, Fitzgerald, R, Kim, S.M, Quinn, M, Haider, S, Appt, S, Frolinger, T, Rosen, C.J, Lizneva, D, Gupta, Y.K, Yuen, T, Zaidi, M.Show

J.Clin.Invest. 135 ? ? (2025)

PMID: 40663423 DOI: 10.1172/JCI182702

Primary Citation of related structures

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