8VMK image
Deposition Date 2024-01-13
Release Date 2025-08-27
Last Version Date 2026-03-25
Entry Detail
PDB ID:
8VMK
Title:
A crystal structure of heme-dependent tyrosine hydroxylase complexed with a substrate analog, 3-(4-hydroxyphenyl)propionic acid
Biological Source:
Source Organism(s):
Expression System(s):
Method Details:
Experimental Method:
Resolution:
1.56 Å
R-Value Free:
0.21
R-Value Work:
0.18
R-Value Observed:
0.18
Space Group:
P 1 21 1
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Heme-dependent L-tyrosine hyd
Chain IDs:A, B
Chain Length:316
Number of Molecules:2
Biological Source:Streptomyces sclerotialus
Primary Citation
Substrate Analogs Implicate a Free Radical Pathway in Tyrosine Hydroxylase Catalysis.
Acs Catalysis 15 18270 18281 (2025)
PMID: 41737883 DOI: 10.1021/acscatal.5c05776
Primary Citation of related structures
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