ISDA: 8UIO

Deposition Date 2023-10-10

Release Date 2025-03-19

Last Version Date 2026-07-15

Entry Detail

PDB ID:

8UIO

Keywords:

IMMUNE SYSTEM

Title:

anti-Phosphohistidine Fab hSC44.ck

Biological Source:

Source Organism(s):

Oryctolagus cuniculus (Taxon ID: 9986)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.75 Å

R-Value Free:

0.23

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 21 21 2

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Macromolecular Entities

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:hSC44.ck Fab heavy chain
Chain IDs:A (auth: H), C (auth: A)
Chain Length:225
Number of Molecules:2
Biological Source:Oryctolagus cuniculus

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:hSC44.ck Fab light chain
Chain IDs:B (auth: L), D (auth: B)
Chain Length:218
Number of Molecules:2
Biological Source:Oryctolagus cuniculus

Ligand Molecules

CIT

Primary Citation

Using phage display for rational engineering of a higher-affinity humanized 3' phosphohistidine-specific antibody.

Martyn, G.D, Kalagiri, R, Veggiani, G, Stanfield, R.L, Choudhuri, I, Sala, M, Meisenhelder, J, Chen, C, Biswas, A, Levy, R.M, Lyumkis, D, Wilson, I.A, Hunter, T, Sidhu, S.S.Show

Commun Chem 8 381 381 (2025)

PMID: 41310398 DOI: 10.1038/s42004-025-01768-9

Primary Citation of related structures

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