8UHN image
Deposition Date 2023-10-09
Release Date 2025-03-19
Last Version Date 2026-07-15
Entry Detail
PDB ID:
8UHN
Keywords:
IMMUNE SYSTEM
Title:
anti-Phosphohistidine Fab hSC44.ck.20.N32F with 3pHis peptide
Biological Source:
Source Organism(s):
Oryctolagus cuniculus (Taxon ID: 9986)
synthetic construct (Taxon ID: 32630)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.09 Å
R-Value Free:
0.24
R-Value Work:
0.21
R-Value Observed:
0.21
Space Group:
P 21 21 21
8UHN validation report missing
Macromolecular Entities
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:3pHis peptide
Chain IDs:E (auth: C), F (auth: D)
Chain Length:9
Number of Molecules:2
Biological Source:synthetic construct
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:hSC44.ck.20.N32F Fab heavy ch
Chain IDs:A (auth: H), C (auth: A)
Chain Length:225
Number of Molecules:2
Biological Source:Oryctolagus cuniculus
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:hSC44.ck.20.N32F Fab light ch
Chain IDs:B (auth: L), D (auth: B)
Chain Length:218
Number of Molecules:2
Biological Source:Oryctolagus cuniculus
Ligand Molecules
ACT
EDO
Primary Citation
Using phage display for rational engineering of a higher-affinity humanized 3' phosphohistidine-specific antibody.
Commun Chem 8 381 381 (2025)
PMID: 41310398 DOI: 10.1038/s42004-025-01768-9
Primary Citation of related structures
8UHN
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