ISDA: 8UCO

Deposition Date 2023-09-26

Release Date 2024-10-09

Last Version Date 2024-10-09

Entry Detail

PDB ID:

8UCO

Keywords:

MEMBRANE PROTEIN

Title:

CryoEM structure of Komagataella pastoris Cytochrome c oxidase (9 subunits) in complex with human VMAT2 and Amphetamine

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Komagataella pastoris (Taxon ID: 4922)

Expression System(s):

Komagataella pastoris

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.25 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Synaptic vesicular amine tran
Gene (Uniprot):SLC18A2
Chain IDs:A
Chain Length:514
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q05940 Pfam ID:PF07690

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome c oxidase subunit
Gene (Uniprot):COX1
Chain IDs:B (auth: a)
Chain Length:514
Number of Molecules:1
Biological Source:Komagataella pastoris

UniProt ID:F2R0K8 Pfam ID:PF00115

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome c oxidase subunit
Chain IDs:C (auth: b)
Chain Length:236
Number of Molecules:1
Biological Source:Komagataella pastoris

UniProt ID:F2R0J7 Pfam ID:PF02790, PF00116

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome c oxidase subunit
Gene (Uniprot):PP7435_Mit-0015
Chain IDs:D (auth: c)
Chain Length:268
Number of Molecules:1
Biological Source:Komagataella pastoris

UniProt ID:F2R0J6 Pfam ID:PF00510

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome c oxidase subunit
Gene (Uniprot):COX4
Chain IDs:E (auth: d)
Chain Length:117
Number of Molecules:1
Biological Source:Komagataella pastoris

UniProt ID:F2QT92 Pfam ID:PF01215

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome c oxidase subunit
Gene (Uniprot):COX5B
Chain IDs:F (auth: e)
Chain Length:124
Number of Molecules:1
Biological Source:Komagataella pastoris

UniProt ID:F2QVW8 Pfam ID:PF02936

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome c oxidase subunit
Gene (Uniprot):COX6
Chain IDs:G (auth: f)
Chain Length:100
Number of Molecules:1
Biological Source:Komagataella pastoris

UniProt ID:F2QVA2 Pfam ID:PF02284

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome c oxidase subunit
Gene (Uniprot):COX7
Chain IDs:H (auth: g)
Chain Length:58
Number of Molecules:1
Biological Source:Komagataella pastoris

UniProt ID:F2QS38 Pfam ID:PF02238

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome c oxidase subunit
Gene (Uniprot):COX8
Chain IDs:I (auth: h)
Chain Length:48
Number of Molecules:1
Biological Source:Komagataella pastoris

UniProt ID:F2QRE4 Pfam ID:PF02935

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytochrome c oxidase subunit
Gene (Uniprot):COX9
Chain IDs:J (auth: i)
Chain Length:56
Number of Molecules:1
Biological Source:Komagataella pastoris

UniProt ID:A0A1G4KPQ9

Ligand Molecules