8TMI image
Deposition Date 2023-07-29
Release Date 2025-02-12
Last Version Date 2026-02-25
Entry Detail
PDB ID:
8TMI
Keywords:
MEMBRANE PROTEIN
Title:
Cryo-EM structure of CorA in complex with conformation-specific synthetic antibody C18 and 100 uM MgCl2, State MG0.1-2C
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Thermotoga maritima (Taxon ID: 2336)
Expression System(s):
Escherichia coli bl21, Escherichia coli 'bl21-gold(de3)plyss ag'
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.30 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
8TMI validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cobalt/magnesium transport pr
Gene (Uniprot):corA
Chain IDs:E (auth: A), F (auth: B), G (auth: C), H (auth: D), I (auth: E)
Chain Length:373
Number of Molecules:5
Biological Source:Thermotoga maritima
UniProt ID:Q9WZ31 Pfam ID:PF01544 EC:7.2.2.14
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:sAB C18 Heavy Chain
Chain IDs:A (auth: H), D (auth: F)
Chain Length:237
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:8TMI
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:sAB C18 Light Chain
Chain IDs:B (auth: L), C (auth: G)
Chain Length:215
Number of Molecules:2
Biological Source:Homo sapiens
UniProt ID:8TMI
Ligand Molecules
MG
Primary Citation
Conformational ensembles of the magnesium channel CorA reveal structural basis for channel gating.
Proc. Natl. Acad. Sci. U.S.A. 123 e2512532123 e2512532123 (2026)
PMID: 41701836 DOI: 10.1073/pnas.2512532123
Primary Citation of related structures
8TMI
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