ISDA: 8SPA

Deposition Date 2023-05-02

Release Date 2024-05-08

Last Version Date 2026-03-11

Entry Detail

PDB ID:

8SPA

Keywords:

PROTEIN FIBRIL

Title:

Structural insights into cellular control of the human CPEB3 prion, functionally regulated by a labile-amyloid-forming segment

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli 'bl21-gold(de3)plyss ag'

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.00 Å

Aggregation State:

FILAMENT

Reconstruction Method:

HELICAL

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cytoplasmic polyadenylation e
Gene (Uniprot):CPEB3
Chain IDs:A, B, C, D, E
Chain Length:49
Number of Molecules:5
Biological Source:Homo sapiens

UniProt ID:Q8NE35

Ligand Molecules

Primary Citation

Structural insights into functional regulation of the human CPEB3 prion by an amyloid-forming segment.

Flores, M.D, Sawaya, M.R, Boyer, D.R, Zink, S, Tovmasyan, S, Saucedo, A, Richards, L.S, Zee, C.T, Cardenas, J, Fioriti, L, Rodriguez, J.A.Show

Structure 33 1314 1324.e5 (2025)

PMID: 40480223 DOI: 10.1016/j.str.2025.05.007

Primary Citation of related structures

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