ISDA: 8SE4

Deposition Date 2023-04-07

Release Date 2025-08-20

Last Version Date 2026-07-08

Entry Detail

PDB ID:

8SE4

Keywords:

SIGNALING PROTEIN, TRANSFERASE

Title:

Structure of Full-length Human Protein Kinase C Beta 1 (PKCBI) in the Active and Inactive Conformation

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.68 Å

R-Value Free:

0.25

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

C 1 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Protein kinase C beta type
Gene (Uniprot):PRKCB
Chain IDs:A, B
Chain Length:672
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P05771 Pfam ID:PF00130, PF00433, PF00168, PF00069 EC:2.7.11.13

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
SEP	A	SER	modified residue
TPO	A	THR	modified residue

Ligand Molecules

ADN

Primary Citation

Molecular basis of allosteric regulation and pharmaceutical targeting of protein kinase C beta.

Cong, A.T.Q, Witter, T.L, Bruinsma, E.S, Sarkar Bhattacharya, S, Jayaraman, S, Wyatt, S.R, Solverson, J.K, Dugan, M.B, Paluncic, J, Kuffel, M.J, Alvey, J.R, Huynh, H.V, Wu, X, Fields, A.P, Pandey, A, Hawse, J.R, Goetz, M.P, Schellenberg, M.J.Show

Nat Commun ? ? ? (2026)

PMID: 42168197 DOI: 10.1038/s41467-026-73413-5

Primary Citation of related structures

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