8RPN image
Deposition Date 2024-01-16
Release Date 2026-09-02
Last Version Date 2026-09-02
Entry Detail
PDB ID:
8RPN
Keywords:
PROTEIN BINDING
Title:
hJAK3 in complex with LAW931 inhibitor
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Baculovirus expression vector pctdual
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
2.72 Å
R-Value Free:
0.28
R-Value Work:
0.24
R-Value Observed:
0.24
Space Group:
P 1
8RPN validation report missing
Macromolecular Entities
Polymer Type:polypeptide(L)
Molecule:Tyrosine-protein kinase JAK3
Mutagens:C241S
Chain IDs:A, B, C, D
Chain Length:298
Number of Molecules:4
Biological Source:Homo sapiens
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
PTR A TYR modified residue
Ligand Molecules
A1H2B
Primary Citation
Discovery of LAS194046: A Potent and Selective pan-Janus Kinase (JAK) Inhibitor with a Suitable Profile for Inhaled Administration
J.Med.Chem. ? ? ? (2026)
DOI: 10.1021/acs.jmedchem.6c00169
Primary Citation of related structures
8RPN
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