8QSC image
Deposition Date 2023-10-10
Release Date 2025-04-23
Last Version Date 2026-03-04
Entry Detail
PDB ID:
8QSC
Title:
Ternary structure of 14-3-3s, ARAF phosphopeptide (pS214) and compound 22 (1083853).
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Method Details:
Experimental Method:
Resolution:
1.80 Å
R-Value Free:
0.20
R-Value Work:
0.17
R-Value Observed:
0.17
Space Group:
P 2 21 21
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:14-3-3 protein sigma
Gene (Uniprot):SFN
Chain IDs:A, C (auth: J)
Chain Length:236
Number of Molecules:2
Biological Source:Homo sapiens
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:ARAF peptide pS214
Chain IDs:B (auth: H), D (auth: S)
Chain Length:11
Number of Molecules:2
Biological Source:Homo sapiens
Primary Citation
Modulation of the 14-3-3 sigma /C-RAF "Auto"inhibited Complex by Molecular Glues.
J. Am. Chem. Soc. 148 4951 4965 (2026)
PMID: 41617210 DOI: 10.1021/jacs.5c12622
Primary Citation of related structures
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