8QSA image
Deposition Date 2023-10-10
Release Date 2025-04-23
Last Version Date 2026-03-04
Entry Detail
PDB ID:
8QSA
Keywords:
PEPTIDE BINDING PROTEIN
Title:
Ternary structure of 14-3-3s, C-RAF phosphopeptide (pS259) and compound 86 (1084384)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.80 Å
R-Value Free:
0.24
R-Value Work:
0.19
R-Value Observed:
0.19
Space Group:
C 2 2 2
8QSA validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:14-3-3 protein sigma
Gene (Uniprot):SFN
Chain IDs:A
Chain Length:236
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:P31947 Pfam ID:PF00244
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:C-RAF peptide
Chain IDs:B (auth: P)
Chain Length:10
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:8QSA
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
CYS A CYS modified residue
Ligand Molecules
CL
MG
WQ9
Primary Citation
Modulation of the 14-3-3 sigma /C-RAF "Auto"inhibited Complex by Molecular Glues.
J. Am. Chem. Soc. 148 4951 4965 (2026)
PMID: 41617210 DOI: 10.1021/jacs.5c12622
Primary Citation of related structures
8QSA
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