ISDA: 8QAJ

Deposition Date 2023-08-22

Release Date 2024-09-11

Last Version Date 2025-09-24

Entry Detail

PDB ID:

8QAJ

Keywords:

SIGNALING PROTEIN

Title:

NMR solution structure of C-terminal domain of CDNF

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

SOLUTION NMR

Conformers Calculated:

300

Conformers Submitted:

Selection Criteria:

structures with the least restraint violations

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cerebral dopamine neurotrophi
Gene (Uniprot):CDNF
Chain IDs:A
Chain Length:65
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q49AH0 Pfam ID:PF10208

Ligand Molecules

Primary Citation

Non-invasive peripheral delivery of CDNF fragment protects neurons in models of Parkinson's and ALS

Yu, L.Y, Viljakainen, T, Beckett, L, Nam, J, Hyysalo, A, Luningschror, P, Albert, K, Koppinen, T, Hyvarinen, T, Tossavainen, H, Hellman, M, Airavaara, M, Sendtner, M, Permi, P, Lindholm, P, Saarma, M, Voutilainen, M.H.Show

Biorxiv ? ? ? (2025)

DOI: 10.1101/2025.02.09.637291

Primary Citation of related structures

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