ISDA: 8PIO

Deposition Date 2023-06-22

Release Date 2025-01-15

Last Version Date 2026-08-05

Entry Detail

PDB ID:

8PIO

Keywords:

CYTOSOLIC PROTEIN

Title:

Crystal structure of Ser33 in complex with PHP (3-phosphohydroxypyruvate)

Biological Source:

Source Organism(s):

Saccharomyces cerevisiae (Taxon ID: 4932)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.60 Å

R-Value Free:

0.26

R-Value Work:

0.22

R-Value Observed:

0.22

Space Group:

P 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:phosphoglycerate dehydrogenas
Chain IDs:A (auth: F), B (auth: A), C (auth: B), D (auth: C)
Chain Length:469
Number of Molecules:4
Biological Source:Saccharomyces cerevisiae

UniProt ID:P40510 Pfam ID:PF00389, PF02826

Ligand Molecules

GOL

HPV

NAD

Primary Citation

Molecular mechanisms of transhydrogenase activity and allosteric regulation in eukaryotic type II PHGDH Ser33.

Perrone, S, Cifuente, J.O, Mastrella, L, Marina, A, Trastoy, B, Becker-Kettern, J, Conrotte, J.F, Alcaide-Jimenez, A, Corzana, F, Glaab, E, Guerin, M.E, Linster, C.L.Show

Nat Commun ? ? ? (2026)

PMID: 42321184 DOI: 10.1038/s41467-026-74211-9

Primary Citation of related structures

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