8OTZ image
Deposition Date 2023-04-21
Release Date 2023-11-22
Last Version Date 2025-10-01
Entry Detail
PDB ID:
8OTZ
Keywords:
STRUCTURAL PROTEIN
Title:
48-nm repeat of the native axonemal doublet microtubule from bovine sperm
Biological Source:
Source Organism(s):
Bos taurus (Taxon ID: 9913)
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.60 Å
Aggregation State:
FILAMENT
Reconstruction Method:
SINGLE PARTICLE
8OTZ validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP95
Chain IDs:A (auth: 0), KS (auth: V)
Chain Length:438
Number of Molecules:2
Biological Source:Bos taurus
UniProt ID:Q32L77 Pfam ID:PF15139
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Sperm acrosome associated 9
Gene (Uniprot):SPACA9
Chain IDs:B (auth: 0A), C (auth: 0C), D (auth: 0E), E (auth: 0G), F (auth: 0W), G (auth: 0Y), H (auth: 0a), I (auth: 0c), J (auth: 0e), K (auth: 0g), L (auth: 0i), M (auth: 0k), YE (auth: CT), ZE (auth: CU), AF (auth: CV), CF (auth: CX), DF (auth: CY), EF (auth: CZ), FF (auth: Ca), GF (auth: Cb), HF (auth: Cc), IF (auth: Cd), JF (auth: Ce), KF (auth: Cf), LF (auth: Cg), MF (auth: Ch), NF (auth: Ci), OF (auth: Cj), PF (auth: Ck)
Chain Length:450
Number of Molecules:29
Biological Source:Bos taurus
UniProt ID:A0A3Q1MYU9 Pfam ID:PF15120
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Testis specific serine kinase
Gene (Uniprot):TSSK6
Chain IDs:N (auth: 1), O (auth: 2), AV (auth: x)
Chain Length:640
Number of Molecules:3
Biological Source:Bos taurus
UniProt ID:F1N2S7 Pfam ID:PF00069
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:EF-hand domain-containing pro
Gene (Uniprot):EFCAB6
Chain IDs:P (auth: 3), BV (auth: y), CV (auth: z)
Chain Length:164
Number of Molecules:3
Biological Source:Bos taurus
UniProt ID:G5E5A3 Pfam ID:PF08976, PF13499
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:ATP6V1F neighbor
Gene (Uniprot):SPMIP1
Chain IDs:Q (auth: A), OB (auth: B), VD (auth: C)
Chain Length:549
Number of Molecules:3
Biological Source:Bos taurus
UniProt ID:G3X8G1 Pfam ID:PF22589
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Outer dense fiber of sperm ta
Chain IDs:R (auth: A0), MC (auth: BN)
Chain Length:274
Number of Molecules:2
Biological Source:Bos taurus
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Outer dense fiber of sperm ta
Chain IDs:S (auth: A1), T (auth: A2), U (auth: A3), V (auth: A4), W (auth: A5), X (auth: A6), Y (auth: A7), Z (auth: A8), AA (auth: A9), IB (auth: Au), JB (auth: Av), KB (auth: Aw), MB (auth: Ay), NB (auth: Az)
Chain Length:254
Number of Molecules:14
Biological Source:Bos taurus
UniProt ID:G3X6A7
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Tubulin alpha-3 chain
Gene (Uniprot):TUBA3
Chain IDs:BA (auth: AA), DA (auth: AC), FA (auth: AE), HA (auth: AG), JA (auth: AI), LA (auth: AK), NA (auth: AM), ZB (auth: BA), BC, DC (auth: BE), FC (auth: BG), HC (auth: BI), JC (auth: BK), LC (auth: BM), GE (auth: CA), IE (auth: CC), KE (auth: CE), ME (auth: CG), OE (auth: CI), QE (auth: CK), SE (auth: CM), QG (auth: DA), SG (auth: DC), UG (auth: DE), WG (auth: DG), YG (auth: DI), AH (auth: DK), CH (auth: DM), LI (auth: EC), NI (auth: EE), PI (auth: EG), RI (auth: EI), TI (auth: EK), VI (auth: EM), RJ (auth: FC), TJ (auth: FE), VJ (auth: FG), XJ (auth: FI), ZJ (auth: FK), BK (auth: FM), FK (auth: GC), HK (auth: GE), JK (auth: GG), LK (auth: GI), NK (auth: GK), PK (auth: GM), TK (auth: HC), VK (auth: HE), XK (auth: HG), ZK (auth: HI), BL (auth: HK), DL (auth: HM), FL (auth: HO), IL (auth: IC), KL (auth: IE), ML (auth: IG), OL (auth: II), QL (auth: IK), SL (auth: IM), UL (auth: IO), XL (auth: JC), ZL (auth: JE), BM (auth: JG), DM (auth: JI), FM (auth: JK), HM (auth: JM), MM (auth: KC), OM (auth: KE), QM (auth: KG), SM (auth: KI), UM (auth: KK), WM (auth: KM), YM (auth: KO), DN (auth: LC), FN (auth: LE), HN (auth: LG), JN (auth: LI), LN (auth: LK), NN (auth: LM), RN (auth: MC), TN (auth: ME), VN (auth: MG), XN (auth: MI), ZN (auth: MK), BO (auth: MM), FO (auth: NA), HO (auth: NC), JO (auth: NE), LO (auth: NG), NO (auth: NI), PO (auth: NK), TO (auth: OA), VO (auth: OC), XO (auth: OE), ZO (auth: OG), BP (auth: OI), DP (auth: OK), GP (auth: PA), IP (auth: PC), KP (auth: PE), MP (auth: PG), OP (auth: PI), QP (auth: PK), SP (auth: PM), UP (auth: QA), WP (auth: QC), YP (auth: QE), AQ (auth: QG), CQ (auth: QI), EQ (auth: QK), GQ (auth: QM), IQ (auth: RA), KQ (auth: RC), MQ (auth: RE), OQ (auth: RG), QQ (auth: RI), SQ (auth: RK), UQ (auth: RM), WQ (auth: SA), YQ (auth: SC), AR (auth: SE), CR (auth: SG), ER (auth: SI), GR (auth: SK), IR (auth: SM), LR (auth: TC), NR (auth: TE), PR (auth: TG), RR (auth: TI), TR (auth: TK), VR (auth: TM), YR (auth: UC), AS (auth: UE), CS (auth: UG), ES (auth: UI), GS (auth: UK), IS (auth: UM), MS (auth: VC), OS (auth: VE), QS (auth: VG), SS (auth: VI), US (auth: VK), WS (auth: VM), AT (auth: WC), CT (auth: WE), ET (auth: WG), GT (auth: WI), IT (auth: WK), KT (auth: WM)
Chain Length:450
Number of Molecules:149
Biological Source:Bos taurus
UniProt ID:Q32KN8 Pfam ID:PF00091, PF03953 EC:3.6.5.-
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Tubulin beta-4B chain
Gene (Uniprot):TUBB4B
Chain IDs:CA (auth: AB), EA (auth: AD), GA (auth: AF), IA (auth: AH), KA (auth: AJ), MA (auth: AL), AC (auth: BB), CC (auth: BD), EC (auth: BF), GC (auth: BH), IC (auth: BJ), KC (auth: BL), HE (auth: CB), JE (auth: CD), LE (auth: CF), NE (auth: CH), PE (auth: CJ), RE (auth: CL), RG (auth: DB), TG (auth: DD), VG (auth: DF), XG (auth: DH), ZG (auth: DJ), BH (auth: DL), DH (auth: DN), KI (auth: EB), MI (auth: ED), OI (auth: EF), QI (auth: EH), SI (auth: EJ), UI (auth: EL), WI (auth: EN), QJ (auth: FB), SJ (auth: FD), UJ (auth: FF), WJ (auth: FH), YJ (auth: FJ), AK (auth: FL), CK (auth: FN), EK (auth: GB), GK (auth: GD), IK (auth: GF), KK (auth: GH), MK (auth: GJ), OK (auth: GL), QK (auth: GN), SK (auth: HB), UK (auth: HD), WK (auth: HF), YK (auth: HH), AL (auth: HJ), CL (auth: HL), EL (auth: HN), HL (auth: IB), JL (auth: ID), LL (auth: IF), NL (auth: IH), PL (auth: IJ), RL (auth: IL), TL (auth: IN), WL (auth: JB), YL (auth: JD), AM (auth: JF), CM (auth: JH), EM (auth: JJ), GM (auth: JL), IM (auth: JN), LM (auth: KB), NM (auth: KD), PM (auth: KF), RM (auth: KH), TM (auth: KJ), VM (auth: KL), XM (auth: KN), CN (auth: LB), EN (auth: LD), GN (auth: LF), IN (auth: LH), KN (auth: LJ), MN (auth: LL), ON (auth: LN), QN (auth: MB), SN (auth: MD), UN (auth: MF), WN (auth: MH), YN (auth: MJ), AO (auth: ML), CO (auth: MN), EO (auth: N0), GO (auth: NB), IO (auth: ND), KO (auth: NF), MO (auth: NH), OO (auth: NJ), QO (auth: NL), SO (auth: O0), UO (auth: OB), WO (auth: OD), YO (auth: OF), AP (auth: OH), CP (auth: OJ), EP (auth: OL), HP (auth: PB), JP (auth: PD), LP (auth: PF), NP (auth: PH), PP (auth: PJ), RP (auth: PL), VP (auth: QB), XP (auth: QD), ZP (auth: QF), BQ (auth: QH), DQ (auth: QJ), FQ (auth: QL), JQ (auth: RB), LQ (auth: RD), NQ (auth: RF), PQ (auth: RH), RQ (auth: RJ), TQ (auth: RL), XQ (auth: SB), ZQ (auth: SD), BR (auth: SF), DR (auth: SH), FR (auth: SJ), HR (auth: SL), KR (auth: TB), MR (auth: TD), OR (auth: TF), QR (auth: TH), SR (auth: TJ), UR (auth: TL), XR (auth: UB), ZR (auth: UD), BS (auth: UF), DS (auth: UH), FS (auth: UJ), HS (auth: UL), JS (auth: UN), LS (auth: VB), NS (auth: VD), PS (auth: VF), RS (auth: VH), TS (auth: VJ), VS (auth: VL), XS (auth: VN), ZS (auth: WB), BT (auth: WD), DT (auth: WF), FT (auth: WH), HT (auth: WJ), JT (auth: WL), LT (auth: WN)
Chain Length:445
Number of Molecules:153
Biological Source:Bos taurus
UniProt ID:Q3MHM5 Pfam ID:PF00091, PF03953
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Protein Flattop
Chain IDs:OA (auth: AP), PA (auth: AQ), QA (auth: AR), RA (auth: AS)
Chain Length:201
Number of Molecules:4
Biological Source:Bos taurus
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP53
Chain IDs:SA (auth: AT), TA (auth: AU)
Chain Length:254
Number of Molecules:2
Biological Source:Bos taurus
UniProt ID:F1N7G5 Pfam ID:PF13868
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Nucleoside diphosphate kinase
Gene (Uniprot):NME7
Chain IDs:UA (auth: AV), VA (auth: AW)
Chain Length:377
Number of Molecules:2
Biological Source:Bos taurus
UniProt ID:Q5E9Y9 Pfam ID:PF00334, PF25364 EC:2.7.4.6
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:EF-hand domain-containing fam
Gene (Uniprot):EFHC2
Chain IDs:WA (auth: Aa), XA (auth: Ab), YA (auth: Ac), ZA (auth: Ad)
Chain Length:445
Number of Molecules:4
Biological Source:Bos taurus
UniProt ID:A0A3Q1N1R0 Pfam ID:PF06565
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Family with sequence similari
Gene (Uniprot):CIMIP2A
Chain IDs:AB (auth: Al), BB (auth: Am), CB (auth: An), DB (auth: Ao), WB (auth: B7), XC (auth: BY), YC (auth: BZ), ZC (auth: Ba), AD (auth: Bb), BD (auth: Bc), CD (auth: Bd), DD (auth: Be), TE (auth: CN), UE (auth: CO)
Chain Length:320
Number of Molecules:14
Biological Source:Bos taurus
UniProt ID:G3X6E2 Pfam ID:PF10629
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Protein FAM166C
Gene (Uniprot):CIMIP2C
Chain IDs:EB (auth: Ap), FB (auth: Aq), GB (auth: Ar)
Chain Length:201
Number of Molecules:3
Biological Source:Bos taurus
UniProt ID:Q3SZR5 Pfam ID:PF10629
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Outer dense fiber of sperm ta
Chain IDs:HB (auth: At), LB (auth: Ax)
Chain Length:514
Number of Molecules:2
Biological Source:Bos taurus
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Spermatid-specific manchette-
Gene (Uniprot):SPMIP6
Chain IDs:PB (auth: B0), QB (auth: B1), RB (auth: B2), SB (auth: B3), TB (auth: B4), XB (auth: B8), YB (auth: B9), VE (auth: CQ), WE (auth: CR), XE (auth: CS)
Chain Length:304
Number of Molecules:10
Biological Source:Bos taurus
UniProt ID:Q32KP0 Pfam ID:PF15181
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Enkurin
Gene (Uniprot):ENKUR
Chain IDs:UB (auth: B5), VB (auth: B6), TD (auth: By), UD (auth: Bz)
Chain Length:320
Number of Molecules:4
Biological Source:Bos taurus
UniProt ID:E1B836 Pfam ID:PF13864
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Coiled-coil domain-containing
Gene (Uniprot):TEKTL1
Chain IDs:NC (auth: BO), OC (auth: BP), PC (auth: BQ), QC (auth: BR)
Chain Length:500
Number of Molecules:4
Biological Source:Bos taurus
UniProt ID:Q2YDN4 Pfam ID:PF03148
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Protein phosphatase 1 regulat
Gene (Uniprot):SAXO4
Chain IDs:RC (auth: BS), SC (auth: BT)
Chain Length:428
Number of Molecules:2
Biological Source:Bos taurus
UniProt ID:Q2T9T0 Pfam ID:PF15691
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:RIB43A-like with coiled-coils
Gene (Uniprot):RIBC2
Chain IDs:TC (auth: BU), UC (auth: BV), HD (auth: Bi), ID (auth: Bj), JD (auth: Bk)
Chain Length:377
Number of Molecules:5
Biological Source:Bos taurus
UniProt ID:Q32LJ7 Pfam ID:PF05914
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP107
Chain IDs:VC (auth: BW), WC (auth: BX)
Chain Length:196
Number of Molecules:2
Biological Source:Bos taurus
UniProt ID:Q2TA11 Pfam ID:PF22595
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Piercer of microtubule wall 1
Gene (Uniprot):PIERCE1
Chain IDs:ED (auth: Bf), FD (auth: Bg)
Chain Length:136
Number of Molecules:2
Biological Source:Bos taurus
UniProt ID:Q32P67 Pfam ID:PF14892
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Piercer of microtubule wall 2
Gene (Uniprot):PIERCE2
Chain IDs:GD (auth: Bh)
Chain Length:445
Number of Molecules:1
Biological Source:Bos taurus
UniProt ID:A0A3Q1LFK7 Pfam ID:PF14892
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Stabilizer of axonemal microt
Chain IDs:KD (auth: Bl), LD (auth: Bm), MD (auth: Bn), ND (auth: Bo), OD (auth: Bp)
Chain Length:500
Number of Molecules:5
Biological Source:Bos taurus
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Stabilizer of axonemal microt
Chain IDs:PD (auth: Bq), SD (auth: Bu)
Chain Length:338
Number of Molecules:2
Biological Source:Bos taurus
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Meiosis-specific nuclear stru
Gene (Uniprot):MNS1
Chain IDs:QD (auth: Br), RD (auth: Bs)
Chain Length:428
Number of Molecules:2
Biological Source:Bos taurus
UniProt ID:Q2KIQ2 Pfam ID:PF13868
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Tektin-3
Gene (Uniprot):TEKT3
Chain IDs:WD (auth: C0), YD (auth: C2), ZD (auth: C3), AE (auth: C4), BE (auth: C5), CE (auth: C6), DE (auth: C7), EE (auth: C8), FE (auth: C9), EH (auth: DO), LJ (auth: F2), MJ (auth: F3), NJ (auth: F4), OJ (auth: F5), PJ (auth: F6)
Chain Length:490
Number of Molecules:15
Biological Source:Bos taurus
UniProt ID:A6H782 Pfam ID:PF03148
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Tektin-5
Gene (Uniprot):TEKT5
Chain IDs:XD (auth: C1), EG (auth: Cz), GG (auth: D0), HG (auth: D1), IG (auth: D2), JG (auth: D3), KG (auth: D4), LG (auth: D5), MG (auth: D6), NG (auth: D7), OG (auth: D8), PG (auth: D9), FH (auth: DP), GH (auth: DQ), HH (auth: DR), IH (auth: DS), JH (auth: DT), KH (auth: DU), LH (auth: DV), MH (auth: DW), NH (auth: DX), JI (auth: EA), XI (auth: EO), YI (auth: EP), ZI (auth: EQ), AJ (auth: ER)
Chain Length:489
Number of Molecules:26
Biological Source:Bos taurus
UniProt ID:Q2YDI7 Pfam ID:PF03148
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Sperm-associated antigen 8
Gene (Uniprot):SPAG8
Chain IDs:BF (auth: CW)
Chain Length:484
Number of Molecules:1
Biological Source:Bos taurus
UniProt ID:E1BNS6 Pfam ID:PF22584
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Spermatogenesis-associated pr
Chain IDs:QF (auth: Cl)
Chain Length:440
Number of Molecules:1
Biological Source:Bos taurus
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Tektin-1
Gene (Uniprot):TEKT1
Chain IDs:RF (auth: Cm), SF (auth: Cn), TF (auth: Co), UF (auth: Cp)
Chain Length:320
Number of Molecules:4
Biological Source:Bos taurus
UniProt ID:Q32KZ9 Pfam ID:PF03148
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Tektin-2
Gene (Uniprot):TEKT2
Chain IDs:VF (auth: Cq), WF (auth: Cr), XF (auth: Cs), YF (auth: Ct), ZF (auth: Cu), AG (auth: Cv), BG (auth: Cw), CG (auth: Cx), DG (auth: Cy)
Chain Length:304
Number of Molecules:9
Biological Source:Bos taurus
UniProt ID:Q2T9Q6 Pfam ID:PF03148
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein C1orf
Gene (Uniprot):SPMIP3
Chain IDs:FG (auth: D)
Chain Length:549
Number of Molecules:1
Biological Source:Bos taurus
UniProt ID:Q32L72 Pfam ID:PF17670
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:TEPP protein
Chain IDs:OH (auth: DY), PH (auth: DZ), QH (auth: Da), JJ (auth: Ee)
Chain Length:216
Number of Molecules:4
Biological Source:Bos taurus
UniProt ID:Q2YDM5 Pfam ID:PF22574
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein MGC13
Gene (Uniprot):CIMIP3
Chain IDs:RH (auth: Db), SH (auth: Dc), TH (auth: Dd)
Chain Length:192
Number of Molecules:3
Biological Source:Bos taurus
UniProt ID:A0A3Q1LFG5 Pfam ID:PF22581
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Testis expressed 33
Gene (Uniprot):CIMIP4
Chain IDs:UH (auth: De)
Chain Length:272
Number of Molecules:1
Biological Source:Bos taurus
UniProt ID:Q32LI7 Pfam ID:PF15400
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Testis-expressed sequence 37
Gene (Uniprot):SPMIP9
Chain IDs:VH (auth: Df), WH (auth: Dg), XH (auth: Dh)
Chain Length:180
Number of Molecules:3
Biological Source:Bos taurus
UniProt ID:A5PJD8 Pfam ID:PF15217
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Testis-expressed protein 43
Gene (Uniprot):SPMIP10
Chain IDs:YH (auth: Di), ZH (auth: Dj), AI (auth: Dk), BI (auth: Dl)
Chain Length:133
Number of Molecules:4
Biological Source:Bos taurus
UniProt ID:A8SMG2 Pfam ID:PF14983
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Testis expressed 49
Gene (Uniprot):SPMIP11
Chain IDs:CI (auth: Dm)
Chain Length:131
Number of Molecules:1
Biological Source:Bos taurus
UniProt ID:A0A3Q1MT14 Pfam ID:PF22593
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Theg spermatid protein like
Gene (Uniprot):SPMAP2L
Chain IDs:DI (auth: Dn)
Chain Length:450
Number of Molecules:1
Biological Source:Bos taurus
UniProt ID:A0A3Q1MNS9 Pfam ID:PF14912
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:EF-hand domain-containing fam
Gene (Uniprot):EFHB
Chain IDs:EI (auth: E), KJ (auth: F)
Chain Length:877
Number of Molecules:2
Biological Source:Bos taurus
UniProt ID:F1MMV1 Pfam ID:PF13499, PF25325
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Tektin bundle interacting pro
Gene (Uniprot):TEKTIP1
Chain IDs:FI (auth: E1), GI (auth: E2), HI (auth: E3), II (auth: E4)
Chain Length:208
Number of Molecules:4
Biological Source:Bos taurus
UniProt ID:F1MZJ1 Pfam ID:PF15041
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Tektin-4
Gene (Uniprot):TEKT4
Chain IDs:BJ (auth: ES), CJ (auth: ET), DJ (auth: EU), EJ (auth: EV), FJ (auth: EW), GJ (auth: EX), HJ (auth: EY), IJ (auth: EZ)
Chain Length:447
Number of Molecules:8
Biological Source:Bos taurus
UniProt ID:Q2TA38 Pfam ID:PF03148
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Chromosome 7 open reading fra
Chain IDs:DK (auth: G)
Chain Length:584
Number of Molecules:1
Biological Source:Bos taurus
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella- associat
Gene (Uniprot):CFAP210
Chain IDs:RK (auth: H), RU (auth: o)
Chain Length:101
Number of Molecules:2
Biological Source:Bos taurus
UniProt ID:E1BJL9 Pfam ID:PF13868
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:EF-hand domain-containing pro
Gene (Uniprot):EFHC1
Chain IDs:GL (auth: I), MT (auth: X), UT (auth: Y)
Chain Length:640
Number of Molecules:3
Biological Source:Bos taurus
UniProt ID:E1BKH1 Pfam ID:PF06565
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein C10or
Gene (Uniprot):SPMIP5
Chain IDs:VL (auth: J), JM (auth: K), ZM (auth: L), PN (auth: M)
Chain Length:235
Number of Molecules:4
Biological Source:Bos taurus
UniProt ID:A6QPC0 Pfam ID:PF22573
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP144
Chain IDs:KM (auth: K1)
Chain Length:135
Number of Molecules:1
Biological Source:Bos taurus
UniProt ID:A8QW39 Pfam ID:PF14886
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Chromosome 20 C5orf49 homolog
Gene (Uniprot):CFAP90
Chain IDs:AN (auth: L1), BN (auth: L2)
Chain Length:147
Number of Molecules:2
Biological Source:Bos taurus
UniProt ID:A0A3Q1LU45 Pfam ID:PF15074
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Chromosome 19 C17orf98 homolo
Gene (Uniprot):SPMAP1
Chain IDs:DO (auth: N), RO (auth: O)
Chain Length:154
Number of Molecules:2
Biological Source:Bos taurus
UniProt ID:E1BC62 Pfam ID:PF15075
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Chromosome 13 C20orf85 homolo
Gene (Uniprot):CIMIP1
Chain IDs:FP (auth: P)
Chain Length:164
Number of Molecules:1
Biological Source:Bos taurus
UniProt ID:A0A3S5ZPE5 Pfam ID:PF14945
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP68
Chain IDs:TP (auth: Q)
Chain Length:164
Number of Molecules:1
Biological Source:Bos taurus
UniProt ID:Q2T9Q3 Pfam ID:PF06608
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia and flagella associated
Gene (Uniprot):CFAP77
Chain IDs:HQ (auth: R), VQ (auth: S), JR (auth: T), WR (auth: U)
Chain Length:284
Number of Molecules:4
Biological Source:Bos taurus
UniProt ID:A0A3Q1LJD6 Pfam ID:PF14825
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:UPF0602 protein C4orf47 homol
Gene (Uniprot):CFAP96
Chain IDs:YS (auth: W)
Chain Length:438
Number of Molecules:1
Biological Source:Bos taurus
UniProt ID:Q2T9M0 Pfam ID:PF15239
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP20
Chain IDs:NT (auth: XG), OT (auth: XH), PT (auth: XI), QT (auth: XJ), RT (auth: XK), ST (auth: XL), TT (auth: XM)
Chain Length:193
Number of Molecules:7
Biological Source:Bos taurus
UniProt ID:Q6B857 Pfam ID:PF05018
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Parkin coregulated gene prote
Gene (Uniprot):PACRG
Chain IDs:VT (auth: YG), WT (auth: YH), XT (auth: YI), YT (auth: YJ), ZT (auth: YK), AU (auth: YL)
Chain Length:257
Number of Molecules:6
Biological Source:Bos taurus
UniProt ID:A5PK71 Pfam ID:PF10274
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:CFAP97 domain containing 1
Gene (Uniprot):CFAP97D1
Chain IDs:BU (auth: Z), SU (auth: p), TU (auth: q)
Chain Length:164
Number of Molecules:3
Biological Source:Bos taurus
UniProt ID:G3N1Q7 Pfam ID:PF13879
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP45
Chain IDs:CU (auth: a), DU (auth: b), EU (auth: c), FU (auth: d)
Chain Length:549
Number of Molecules:4
Biological Source:Bos taurus
UniProt ID:Q32LN4 Pfam ID:PF13868
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP52
Chain IDs:GU (auth: e), HU (auth: f), IU (auth: g)
Chain Length:877
Number of Molecules:3
Biological Source:Bos taurus
UniProt ID:E1BKF9 Pfam ID:PF00400, PF23409
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP141
Chain IDs:JU (auth: h)
Chain Length:101
Number of Molecules:1
Biological Source:Bos taurus
UniProt ID:Q32L75 Pfam ID:PF15104
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP161
Chain IDs:KU (auth: i), LU (auth: j)
Chain Length:321
Number of Molecules:2
Biological Source:Bos taurus
UniProt ID:F6RJC2 Pfam ID:PF24569
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Dual specificity phosphatase
Gene (Uniprot):DUSP21
Chain IDs:MU (auth: k), OU (auth: l), PU (auth: m), QU (auth: n)
Chain Length:235
Number of Molecules:4
Biological Source:Bos taurus
UniProt ID:Q0II40 Pfam ID:PF00782
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Uncharacterized protein C4orf
Gene (Uniprot):SPMIP2
Chain IDs:NU (auth: ke)
Chain Length:450
Number of Molecules:1
Biological Source:Bos taurus
UniProt ID:Q2KIR0 Pfam ID:PF15123
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Cilia- and flagella-associate
Gene (Uniprot):CFAP276
Chain IDs:UU (auth: r), VU (auth: s), WU (auth: t)
Chain Length:284
Number of Molecules:3
Biological Source:Bos taurus
UniProt ID:E1B9I5 Pfam ID:PF12494
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:EF-hand calcium-binding domai
Gene (Uniprot):EFCAB3
Chain IDs:XU (auth: u), YU (auth: v), ZU (auth: w)
Chain Length:438
Number of Molecules:3
Biological Source:Bos taurus
UniProt ID:Q2T9P0
Ligand Molecules
GDP
GTP
MG
Primary Citation
Structural specializations of the sperm tail.
Cell 186 2880 2896.e17 (2023)
PMID: 37327785 DOI: 10.1016/j.cell.2023.05.026

Abstact

Sperm motility is crucial to reproductive success in sexually reproducing organisms. Impaired sperm movement causes male infertility, which is increasing globally. Sperm are powered by a microtubule-based molecular machine-the axoneme-but it is unclear how axonemal microtubules are ornamented to support motility in diverse fertilization environments. Here, we present high-resolution structures of native axonemal doublet microtubules (DMTs) from sea urchin and bovine sperm, representing external and internal fertilizers. We identify >60 proteins decorating sperm DMTs; at least 15 are sperm associated and 16 are linked to infertility. By comparing DMTs across species and cell types, we define core microtubule inner proteins (MIPs) and analyze evolution of the tektin bundle. We identify conserved axonemal microtubule-associated proteins (MAPs) with unique tubulin-binding modes. Additionally, we identify a testis-specific serine/threonine kinase that links DMTs to outer dense fibers in mammalian sperm. Our study provides structural foundations for understanding sperm evolution, motility, and dysfunction at a molecular level.

Legend

Protein

Chemical

Disease

Primary Citation of related structures
8OTZ
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