8OIN image
Deposition Date 2023-03-23
Release Date 2023-06-14
Last Version Date 2026-09-02
Entry Detail
PDB ID:
8OIN
Keywords:
RIBOSOME
Title:
55S mammalian mitochondrial ribosome with mtRF1 and P-site tRNA
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Sus scrofa (Taxon ID: 9823)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.60 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
8OIN validation report missing
Macromolecular Entities
Polymer Type:polyribonucleotide
Molecule:12S rRNA
Chain IDs:IB (auth: AA)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S35, mi
Gene (Uniprot):MRPS35
Chain IDs:JB (auth: AB)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1SG95 Pfam ID:PF10213
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS24
Chain IDs:KB (auth: AC)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A287ANU4 Pfam ID:PF14955
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):AURKAIP1
Chain IDs:LB (auth: AD)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A8D1P8R7 Pfam ID:PF08213
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitoribosomal protein bs6m, m
Chain IDs:MB (auth: AE)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A5K1V0G5 Pfam ID:PF01250
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS7
Chain IDs:NB (auth: AF)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A286ZJ25 Pfam ID:PF00177
Polymer Type:polyribonucleotide
Molecule:P-site Met-tRNA(fMet)
Chain IDs:OB (auth: AG)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS10
Chain IDs:PB (auth: AH)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1RUU2 Pfam ID:PF00338
Polymer Type:polyribonucleotide
Molecule:mRNA
Chain IDs:QB (auth: AI)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Chain IDs:RB (auth: AJ)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A0M3KL52 Pfam ID:PF00164
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS14
Chain IDs:SB (auth: AK)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A0M3KL53 Pfam ID:PF00253
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S15, mi
Gene (Uniprot):MRPS15
Chain IDs:TB (auth: AL)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A287AKS1 Pfam ID:PF00312
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S16, mi
Chain IDs:UB (auth: AM)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A480JTD7 Pfam ID:PF00886
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S17, mi
Chain IDs:VB (auth: AN)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A8D1IXU1 Pfam ID:PF00366
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S18b, m
Gene (Uniprot):MRPS18B
Chain IDs:WB (auth: AO)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:Q767K8 Pfam ID:PF01084
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS18C
Chain IDs:XB (auth: AP)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A0M3KL54 Pfam ID:PF01084
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S21, mi
Gene (Uniprot):MRPS21
Chain IDs:YB (auth: AQ)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A286ZNB3 Pfam ID:PF01165
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS22
Chain IDs:ZB (auth: AR)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A287AQT5 Pfam ID:PF10245
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:mS23
Gene (Uniprot):MRPS23
Chain IDs:AC (auth: AS)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A287AEW3 Pfam ID:PF10484
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS25
Chain IDs:BC (auth: AT)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A0M3KL55 Pfam ID:PF05047
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):GNRH2
Chain IDs:CC (auth: AU)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A287AY01
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS27
Chain IDs:DC (auth: AV)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A5G2R1I0 Pfam ID:PF10037
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitoribosomal protein ms28, m
Gene (Uniprot):MRPS28
Chain IDs:EC (auth: AW)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A0M3KL56 Pfam ID:PF10246
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Small ribosomal subunit prote
Gene (Uniprot):DAP3
Chain IDs:FC (auth: AX)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A8D1XNL0 Pfam ID:PF10236
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S31, mi
Gene (Uniprot):MRPS31
Chain IDs:GC (auth: AY)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1RME2 Pfam ID:PF15433
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Chain IDs:HC (auth: AZ)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A4X1V2H3 Pfam ID:PF08293
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Peptide chain release factor
Gene (Uniprot):MTRF1
Chain IDs:IC (auth: Aa)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O75570 Pfam ID:PF03462, PF00472
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS2
Chain IDs:JC (auth: Ab)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1S001 Pfam ID:PF00318
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Coiled-coil-helix-coiled-coil
Chain IDs:KC (auth: Ac)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A4X1SZV4 Pfam ID:PF06747
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S5, mit
Gene (Uniprot):MRPS5
Chain IDs:LC (auth: Ad)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1SU66 Pfam ID:PF21251, PF00333, PF03719
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:mS39
Gene (Uniprot):PTCD3
Chain IDs:MC (auth: Ae)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:K7GKS8 Pfam ID:PF22330, PF13812
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:uS9m
Gene (Uniprot):MRPS9
Chain IDs:NC (auth: Ag)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:I3LU08 Pfam ID:PF00380
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS11
Chain IDs:OC (auth: Ai)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A286ZJJ6 Pfam ID:PF00411
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS34
Chain IDs:PC (auth: Aj)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A287AVS9 Pfam ID:PF16053
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL12
Chain IDs:A (auth: B1), B (auth: B2), C (auth: B3), D (auth: B4), E (auth: B5), F (auth: B6)
Chain Length:0
Number of Molecules:6
Biological Source:Sus scrofa
UniProt ID:A0A8D0VGD9 Pfam ID:PF16320, PF00542
Polymer Type:polyribonucleotide
Molecule:E-site tRNA
Chain IDs:G (auth: B7)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
Polymer Type:polyribonucleotide
Molecule:16S rRNA
Chain IDs:H (auth: B8)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
Polymer Type:polyribonucleotide
Molecule:CP Phe-tRNA
Chain IDs:I (auth: B9)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):MRPL22
Chain IDs:J (auth: BA)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A4X1TXR4 Pfam ID:PF00237
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L23, mi
Gene (Uniprot):MRPL23
Chain IDs:K (auth: BB)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A480JJI1 Pfam ID:PF00276
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:uL24m
Gene (Uniprot):MRPL24
Chain IDs:L (auth: BC)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1RHJ1 Pfam ID:PF00467, PF17136
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L27, mi
Chain IDs:M (auth: BD)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A4X1U0F6 Pfam ID:PF01016
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL28
Chain IDs:N (auth: BE)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A286ZTW8 Pfam ID:PF00830
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL47
Chain IDs:O (auth: BF)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1SGC7 Pfam ID:PF06984
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Chain IDs:P (auth: BG)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A8D0VJF4 Pfam ID:PF00327
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL32
Chain IDs:Q (auth: BH)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:I3LTC4 Pfam ID:PF01783
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):MRPL33
Chain IDs:R (auth: BI)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A4X1TLP9 Pfam ID:PF00471
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):MRPL34
Chain IDs:S (auth: BJ)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A8D1JE64 Pfam ID:PF00468
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L35, mi
Gene (Uniprot):MRPL35
Chain IDs:T (auth: BK)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A5G2QZK0 Pfam ID:PF01632
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL2
Chain IDs:U (auth: BL)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A287A143 Pfam ID:PF03947, PF00181
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:ICT1
Gene (Uniprot):MRPL3
Chain IDs:V (auth: BM)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A140UHW4 Pfam ID:PF00297
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL4
Chain IDs:W (auth: BN)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A287B9C4 Pfam ID:PF00573
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL9
Chain IDs:X (auth: BO)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:I3LR45 Pfam ID:PF01281, PF22078, PF25131
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL10
Chain IDs:Y (auth: BP)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1RWJ0 Pfam ID:PF00466
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL11
Chain IDs:Z (auth: BQ)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1RU54 Pfam ID:PF00298
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L13, mi
Gene (Uniprot):MRPL13
Chain IDs:AA (auth: BR)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:K7GP19 Pfam ID:PF00572
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL14
Chain IDs:BA (auth: BS)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A287BMZ6 Pfam ID:PF00238
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L15, mi
Chain IDs:CA (auth: BT)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A8D0HMG9 Pfam ID:PF00828
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:uL16m
Gene (Uniprot):MRPL16
Chain IDs:DA (auth: BU)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1RI89 Pfam ID:PF00252
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:bL17m
Gene (Uniprot):MRPL17
Chain IDs:EA (auth: BV)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1RMQ4 Pfam ID:PF01196
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL18
Chain IDs:FA (auth: BW)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A4X1VX01 Pfam ID:PF00861
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L19, mi
Gene (Uniprot):MRPL19
Chain IDs:GA (auth: BX)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:I3LNJ0 Pfam ID:PF01245
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL20
Chain IDs:HA (auth: BY)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A286ZU56 Pfam ID:PF00453
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Chain IDs:IA (auth: BZ)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1RY70 Pfam ID:PF00829
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L52, mi
Gene (Uniprot):MRPL52
Chain IDs:JA (auth: Ba)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1S9B7 Pfam ID:PF18699
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Chain IDs:KA (auth: Bb)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:mL54
Gene (Uniprot):MRPL54
Chain IDs:LA (auth: Bc)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:I3LN63 Pfam ID:PF08561
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL55
Chain IDs:MA (auth: Bd)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A4X1ULI6 Pfam ID:PF09776
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL57
Chain IDs:NA (auth: Be)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A287BP93 Pfam ID:PF14978
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:mL62 (ICT1)
Gene (Uniprot):MRPL58
Chain IDs:OA (auth: Bf)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A286ZJR2 Pfam ID:PF00472
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:mL64
Gene (Uniprot):GADD45GIP1
Chain IDs:PA (auth: Bg)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A286ZXA6 Pfam ID:PF10147
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS18A
Chain IDs:QA (auth: Bh)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1RRH6 Pfam ID:PF01084
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein S30, mi
Gene (Uniprot):MRPS30
Chain IDs:RA (auth: Bi)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A480QIM3 Pfam ID:PF07147
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L1, mit
Gene (Uniprot):MRPL1
Chain IDs:SA (auth: Bj)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A287AF82 Pfam ID:PF00687
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal protein
Gene (Uniprot):MRPL36
Chain IDs:TA (auth: Bl)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A287A731 Pfam ID:PF00444
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL37
Chain IDs:UA (auth: Bm)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A287BIV6 Pfam ID:PF07147
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL38
Chain IDs:VA (auth: Bn)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1RW03 Pfam ID:PF01161
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL39
Chain IDs:WA (auth: Bo)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1SHP6
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL40
Chain IDs:XA (auth: Bp)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A286ZP98 Pfam ID:PF09812
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L41, mi
Chain IDs:YA (auth: Bq)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A8D1BPA5 Pfam ID:PF09809
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:mL42
Gene (Uniprot):MRPL42
Chain IDs:ZA (auth: Br)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A287BQA1 Pfam ID:PF10210
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Gene (Uniprot):MRPL43
Chain IDs:AB (auth: Bs)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1S8U4 Pfam ID:PF05047
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:mL44
Gene (Uniprot):MRPL44
Chain IDs:BB (auth: Bt)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1SR64 Pfam ID:PF22935, PF22892
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL45
Chain IDs:CB (auth: Bu)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:I3LGM5 Pfam ID:PF04280
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL46
Chain IDs:DB (auth: Bv)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1SRT0 Pfam ID:PF11788
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L48, mi
Gene (Uniprot):MRPL48
Chain IDs:EB (auth: Bw)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A480J9Z6 Pfam ID:PF00338
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mrpl34
Gene (Uniprot):MRPL49
Chain IDs:FB (auth: Bx)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A0R4J8D6 Pfam ID:PF05046
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL50
Chain IDs:GB (auth: By)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:I3L9H6 Pfam ID:PF10501
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Large ribosomal subunit prote
Chain IDs:HB (auth: Bz)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A8D1VKN8 Pfam ID:PF10244
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
AYA K ALA modified residue
SAC AA SER modified residue
Ligand Molecules
ATP
FES
FME
GDP
K
MG
PHE
SPD
SPM
ZN
Primary Citation
Molecular basis of translation termination at noncanonical stop codons in human mitochondria.
Science 380 531 536 (2023)
PMID: 37141370 DOI: 10.1126/science.adf9890

Abstact

The genetic code that specifies the identity of amino acids incorporated into proteins during protein synthesis is almost universally conserved. Mitochondrial genomes feature deviations from the standard genetic code, including the reassignment of two arginine codons to stop codons. The protein required for translation termination at these noncanonical stop codons to release the newly synthesized polypeptides is not currently known. In this study, we used gene editing and ribosomal profiling in combination with cryo-electron microscopy to establish that mitochondrial release factor 1 (mtRF1) detects noncanonical stop codons in human mitochondria by a previously unknown mechanism of codon recognition. We discovered that binding of mtRF1 to the decoding center of the ribosome stabilizes a highly unusual conformation in the messenger RNA in which the ribosomal RNA participates in specific recognition of the noncanonical stop codons.

Legend

Protein

Chemical

Disease

Primary Citation of related structures
8OIN
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