ISDA: 8IU2

Deposition Date 2023-03-23

Release Date 2024-03-27

Last Version Date 2026-06-24

Entry Detail

PDB ID:

8IU2

Keywords:

MEMBRANE PROTEIN

Title:

Cryo-EM structure of Long-wave-sensitive opsin 1

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
Bos taurus (Taxon ID: 9913)

Expression System(s):

Spodoptera frugiperda

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.35 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNAI1
Mutagens:S47C, G202T, G203A, E245A, A326S
Chain IDs:B (auth: A)
Chain Length:354
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P63096 Pfam ID:PF00503

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNB1
Chain IDs:C (auth: B)
Chain Length:340
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P62873 Pfam ID:PF00400, PF25391

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Guanine nucleotide-binding pr
Gene (Uniprot):GNG2
Chain IDs:D (auth: G)
Chain Length:71
Number of Molecules:1
Biological Source:Bos taurus

UniProt ID:P63212 Pfam ID:PF00631

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Long-wave-sensitive opsin 1
Gene (Uniprot):OPN1LW
Mutagens:E129Q
Chain IDs:A (auth: R)
Chain Length:364
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P04000 Pfam ID:PF00001

Protein Blast

Polymer Type:polypeptide(L)
Molecule:scFv Recombinant Human Monocl
Chain IDs:E (auth: S)
Chain Length:259
Number of Molecules:1
Biological Source:Homo sapiens

Ligand Molecules

RET

Primary Citation

Cryo-electron microscopy structures of human cone visual pigments

Peng, Q, Li, J, Jiang, H, Cheng, X, Nag, P, Kleinau, G, Lamb, T.D, Busche, L, Lu, Q, Zhou, S, Liu, Y, Zhang, Y, Lv, S, Wan, S, Yang, T, Chen, Y, Zhang, W, Nan, W, Fu, Y, Che, T, Li, Y, Liao, H, Duan, J, Schapiro, I, Scheerer, P, Zhang, J.Show

Science ? ? ? (2026)

DOI: 10.1126/science.adz8141

Primary Citation of related structures

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