ISDA: 8I5D

Deposition Date 2023-01-25

Release Date 2023-08-23

Last Version Date 2024-10-16

Entry Detail

PDB ID:

8I5D

Keywords:

IMMUNE SYSTEM

Title:

Crystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS peptide (VVGAVGVGK)

Biological Source:

Source Organism(s):

Mus musculus (Taxon ID: 10090)
Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

3.30 Å

R-Value Free:

0.25

R-Value Work:

0.23

R-Value Observed:

0.23

Space Group:

P 62 2 2

Download Validation Report

Macromolecular Entities

Protein Blast

Polymer Type:polypeptide(L)
Molecule:TCR alpha chain
Chain IDs:A
Chain Length:194
Number of Molecules:1
Biological Source:Mus musculus

Protein Blast

Polymer Type:polypeptide(L)
Molecule:TCR beta chain
Chain IDs:B
Chain Length:242
Number of Molecules:1
Biological Source:Mus musculus

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:MHC class I antigen (Fragment
Gene (Uniprot):HLA-A
Mutagens:A245V,E253Q
Chain IDs:C (auth: H)
Chain Length:274
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:U5YJJ6 Pfam ID:PF00129, PF07654

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Beta-2-microglobulin
Gene (Uniprot):B2M
Chain IDs:D (auth: L)
Chain Length:99
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P61769 Pfam ID:PF07654

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:peptide KRAS-G12V-9
Mutagens:G12V
Chain IDs:E (auth: P)
Chain Length:9
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P01116

Ligand Molecules

Primary Citation

Crystal structure of a TCR in complex with HLA-A*11:01 bound to KRAS peptide (VVGAVGVGK)

Lu, D, Chen, Y, Jiang, M, Tan, S.G, Chai, Y, Gao, G.F.Show

Nat Commun ? ? ? (2023)

Primary Citation of related structures

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