ISDA: 8HMQ

Deposition Date 2022-12-05

Release Date 2023-01-11

Last Version Date 2024-05-29

Entry Detail

PDB ID:

8HMQ

Keywords:

TRANSFERASE

Title:

Crystal Structure of PKM2 mutant P403A

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.50 Å

R-Value Free:

0.26

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Pyruvate kinase PKM
Gene (Uniprot):PKM
Mutagens:P403A
Chain IDs:A, B, C, D
Chain Length:551
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:P14618 Pfam ID:PF00224, PF02887 EC:2.7.1.40

Ligand Molecules

EDO

FBP

GOL

OXL

Primary Citation

Structural and mechanistic insights into cancer patient-derived mutations in Pyruvate Kinase muscle isoform 2

Upadhyay, S, Kumar, A, Patel, A.K.Show

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Primary Citation of related structures

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