8DZI image
Deposition Date 2022-08-07
Release Date 2022-08-31
Last Version Date 2025-05-14
Entry Detail
PDB ID:
8DZI
Keywords:
VIRAL PROTEIN/IMMUNE SYSTEM
Title:
Structure of SARS-CoV-2 Omicron BA.1.1.529 Spike trimer with one RBD down in complex with the Fab fragment of human neutralizing antibody MB.02
Biological Source:
Source Organism(s):
Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Homo sapiens
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
3.50 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
8DZI validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Spike glycoprotein
Gene (Uniprot):S
Chain IDs:A (auth: C), D (auth: A), G (auth: E)
Chain Length:1285
Number of Molecules:3
Biological Source:Severe acute respiratory syndrome coronavirus 2
UniProt ID:P0DTC2 Pfam ID:PF16451, PF09408, PF19209, PF01601
Protein Blast
Polymer Type:polypeptide(L)
Molecule:antibody MB.02 heavy chain
Chain IDs:B (auth: H), E (auth: B), I (auth: G)
Chain Length:118
Number of Molecules:3
Biological Source:Homo sapiens
Protein Blast
Polymer Type:polypeptide(L)
Molecule:antibody MB.02 light chain
Chain IDs:C (auth: L), F (auth: D), H (auth: F)
Chain Length:109
Number of Molecules:3
Biological Source:Homo sapiens
Ligand Molecules
NAG
Primary Citation
Function and Cryo-EM structures of broadly potent bispecific antibodies against multiple SARS-CoV-2 Omicron sublineages.
Signal Transduct Target Ther 8 281 281 (2023)
PMID: 37518189 DOI: 10.1038/s41392-023-01509-1
Primary Citation of related structures
8DZI
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