ISDA: 8BB2

Deposition Date 2022-10-12

Release Date 2022-11-09

Last Version Date 2024-01-31

Entry Detail

PDB ID:

8BB2

Keywords:

LIGASE

Title:

Structure of human WDR5 and pVHL:ElonginC:ElonginB bound to PROTAC with PEG linker (conformation #2)

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.05 Å

R-Value Free:

0.23

R-Value Work:

0.19

R-Value Observed:

0.20

Space Group:

P 21 21 21

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:WD repeat-containing protein
Gene (Uniprot):WDR5
Chain IDs:A (auth: B)
Chain Length:321
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P61964 Pfam ID:PF00400, PF25175

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Elongin-B
Gene (Uniprot):ELOB
Chain IDs:B (auth: J)
Chain Length:104
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q15370 Pfam ID:PF00240

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Elongin-C
Gene (Uniprot):ELOC
Chain IDs:C (auth: K)
Chain Length:98
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q15369 Pfam ID:PF03931

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:von Hippel-Lindau disease tum
Gene (Uniprot):VHL
Chain IDs:D (auth: L)
Chain Length:162
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P40337 Pfam ID:PF01847, PF17211 EC:2.3.2.B13

Ligand Molecules