ISDA: 8AKB

Deposition Date 2022-07-29

Release Date 2023-08-16

Last Version Date 2026-03-04

Entry Detail

PDB ID:

8AKB

Keywords:

HYDROLASE

Title:

Human Sirt6 in complex with ADP-ribose and fragment 4-nitrocatechol

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.13 Å

R-Value Free:

0.26

R-Value Work:

0.21

R-Value Observed:

0.21

Space Group:

P 63

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:NAD-dependent protein deacety
Gene (Uniprot):SIRT6
Chain IDs:A, B
Chain Length:302
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:Q8N6T7 Pfam ID:PF02146 EC:2.3.1.B41

Ligand Molecules

4NC

AR6

EDO

PEG

SO4

Primary Citation

Development of novel Sirtuin 6 inhibitors and activators based on a protein crystallography-based fragment screen

You, W, Steegborn, C.Show

To be published ? ? ? (?)

Primary Citation of related structures

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