ISDA: 7WO0

Deposition Date 2022-01-20

Release Date 2023-01-25

Last Version Date 2024-06-26

Entry Detail

PDB ID:

7WO0

Keywords:

PROTEIN FIBRIL

Title:

CryoEM structure of human alpha-synuclein A53T fibril induced by calcium ions

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

2.70 Å

Aggregation State:

FILAMENT

Reconstruction Method:

HELICAL

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Alpha-synuclein
Gene (Uniprot):SNCA
Chain IDs:A (auth: C), B (auth: A), C (auth: B), D, E, F, G, H (auth: O), I (auth: P), J (auth: Q), K (auth: R), L (auth: S), M (auth: T), N (auth: U)
Chain Length:65
Number of Molecules:14
Biological Source:Homo sapiens

UniProt ID:P37840 Pfam ID:PF01387

Ligand Molecules

Primary Citation

Calcium abolishes intramolecular long-range contacts and promotes hereditary alpha-synuclein A53T aggregation

Huang, J.Y.-C, Wu, K.-P.Show

To be published ? ? ? (?)

Primary Citation of related structures

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