ISDA: 7UEV

Deposition Date 2022-03-22

Release Date 2023-03-29

Last Version Date 2026-04-22

Entry Detail

PDB ID:

7UEV

Keywords:

TRANSFERASE/TRANSFERASE INHIBITOR

Title:

PANK3 complex structure with compound PZ-4200

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.80 Å

R-Value Free:

0.21

R-Value Work:

0.17

R-Value Observed:

0.17

Space Group:

P 31 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Pantothenate kinase 3
Gene (Uniprot):PANK3
Chain IDs:A
Chain Length:380
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:Q9H999 Pfam ID:PF03630 EC:2.7.1.33

Ligand Molecules

ACT

ANP

EDO

N0I

Primary Citation

Discovery of Sulfonamide Pantothenate Kinase Activators and Elucidation of the Role of Isoform Selectivity in Cellular Pantothenate Kinase Activation.

Coker, A.L, Tangallapally, R, Yun, M.K, Subramanian, C, Jayasinghe, T, Miller, K, Edwards, A, Frank, M, Jackowski, S, Rock, C.O, White, S.W, Lee, R.E.Show

J. Med. Chem. 69 6004 6013 (2026)

PMID: 41771535 DOI: 10.1021/acs.jmedchem.5c03452

Primary Citation of related structures

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