ISDA: 7RZI

Deposition Date 2021-08-27

Release Date 2022-08-31

Last Version Date 2026-06-10

Entry Detail

PDB ID:

7RZI

Keywords:

HYDROLASE

Title:

Insulin Degrading Enzyme pC/pC

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli, Saccharomyces cerevisiae

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.00 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Cysteine-free Insulin-degradi
Gene (Uniprot):IDE
Mutagens:C110L, C171S, C178A, C257V, C414L, C573N, C590S, C789S, C812A, C819A, C904S, C966S, C974S
Chain IDs:A, B
Chain Length:1011
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P14735 Pfam ID:PF00675, PF05193, PF16187 EC:3.4.24.56

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Insulin A chain
Gene (Uniprot):INS
Chain IDs:C (auth: a), E (auth: c)
Chain Length:1011
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P01308 Pfam ID:PF00049

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Insulin B chain
Gene (Uniprot):INS
Chain IDs:D (auth: b), F (auth: d)
Chain Length:30
Number of Molecules:2
Biological Source:Homo sapiens

UniProt ID:P01308 Pfam ID:PF00049

Ligand Molecules

Primary Citation

Characterization and modulation of human insulin degrading enzyme conformational dynamics to control enzyme activity

Mancl, J.M, Liang, W.G, Bayhi, N.L, Wei, H, Budell, W, Mendez, J.H, Sosnick, T.R, Carragher, B, Potter, C.S, Tang, W.J.Show

Elife ? ? ? (2026)

DOI: 10.7554/elife.105761.3

Primary Citation of related structures

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