ISDA: 7PUX

Deposition Date 2021-10-01

Release Date 2022-12-14

Last Version Date 2024-01-31

Entry Detail

PDB ID:

7PUX

Keywords:

HYDROLASE

Title:

Structure of p97 N-D1(L198W) in complex with Fragment TROLL2

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.73 Å

R-Value Free:

0.23

R-Value Work:

0.19

R-Value Observed:

0.19

Space Group:

P 6 2 2

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Transitional endoplasmic reti
Gene (Uniprot):VCP
Mutagens:L198W
Chain IDs:A
Chain Length:468
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P55072 Pfam ID:PF02359, PF02933, PF00004, PF17862 EC:3.6.4.6

Ligand Molecules

6LY

ADP

FMT

PEG

Primary Citation

Fragment screening using biolayer interferometry reveals ligands targeting the SHP-motif binding site of the AAA+ ATPase p97

Bothe, S, Hanzelmann, P, Bohler, S, Kehrein, J, Zehe, M, Wiedemann, C, Hellmich, U.A, Brenk, R, Schindelin, H, Sotriffer, C.Show

Commun Chem 5 169 ? (2022)

DOI: 10.1038/s42004-022-00782-5

Primary Citation of related structures

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