ISDA: 7PAA

Deposition Date 2021-07-29

Release Date 2023-02-08

Last Version Date 2026-10-21

Entry Detail

PDB ID:

7PAA

Keywords:

VIRAL PROTEIN

Title:

JC polyomavirus VP1 in complex with scFv 29B1

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)
JC polyomavirus (Taxon ID: 10632)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

3.10 Å

R-Value Free:

0.24

R-Value Work:

0.22

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Structural Superimposition Protein Blast

Polymer Type:polypeptide(L)
Molecule:Major capsid protein VP1
Chain IDs:B (auth: AAA), C (auth: BBB), D (auth: CCC), E (auth: DDD), F (auth: EEE), G (auth: FFF), H (auth: GGG), I (auth: HHH), J (auth: III), K (auth: JJJ)
Chain Length:272
Number of Molecules:10
Biological Source:JC polyomavirus

UniProt ID:P03089 Pfam ID:PF00718

Polymer Type:polypeptide(L)
Molecule:scFv 29B1
Chain IDs:A (auth: ZZZ), L (auth: KKK), M (auth: aaa), N (auth: bbb), O (auth: ccc), P (auth: ddd), Q (auth: eee), R (auth: WWW), S (auth: XXX), T (auth: YYY)
Chain Length:252
Number of Molecules:10
Biological Source:Homo sapiens

Primary Citation

Structural characterization of human neutralizing antibodies against JC and BK polyomaviruses.

Harprecht, C, Stroh, L.J, O'Hara, B.A, Freytag, J, Nagel, F, Haley, S.A, Stierhof, Y.D, Atwood, W.J, Stehle, T.Show

Proc.Natl.Acad.Sci.USA 123 e2603048123 e2603048123 (2026)

PMID: 42406959 DOI: 10.1073/pnas.2603048123

Primary Citation of related structures

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