ISDA: 7O9N

Deposition Date 2021-04-16

Release Date 2022-05-04

Last Version Date 2025-08-06

Entry Detail

PDB ID:

7O9N

Keywords:

HYDROLASE

Title:

OXA-48 with carbamylated Lys73 in complex with bicarbonate ions at neutral pH

Biological Source:

Source Organism(s):

Klebsiella pneumoniae (Taxon ID: 573)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.97 Å

R-Value Free:

0.28

R-Value Work:

0.19

Space Group:

P 21 21 21

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Beta-lactamase
Gene (Uniprot):OXA-48
Chain IDs:A (auth: AAA), B (auth: BBB), C (auth: CCC), D (auth: DDD)
Chain Length:260
Number of Molecules:4
Biological Source:Klebsiella pneumoniae

UniProt ID:Q6XEC0 Pfam ID:PF00905 EC:3.5.2.6

Modified Residue

Compound ID	Chain ID	Parent Comp ID	Details	2D Image
KCX	A	LYS	modified residue

Ligand Molecules

BCT

Primary Citation

An Ion-Pair Induced Intermediate Complex Captured in Class D Carbapenemase Reveals Chloride Ion as a Janus Effector Modulating Activity

Zhou, Q, Catalan, P, Bell, H, Baumann, P, Cooke, R, Evans, R, Yang, J, Zhang, Z, Zappala, D, Zhang, Y, Blackburn, G.M, He, Y, Jin, Y.Show

Acs Cent.Sci. ? ? ? (2023)

DOI: 10.1021/acscentsci.3c00609

Primary Citation of related structures

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