7NSI image
Deposition Date 2021-03-07
Release Date 2021-06-02
Last Version Date 2026-06-24
Entry Detail
PDB ID:
7NSI
Keywords:
TRANSLATION
Title:
55S mammalian mitochondrial ribosome with mtRRF (pre) and tRNA(P/E)
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Sus scrofa (Taxon ID: 9823)
Expression System(s):
Escherichia coli
Method Details:
Experimental Method:
ELECTRON MICROSCOPY
Resolution:
4.60 Å
Aggregation State:
PARTICLE
Reconstruction Method:
SINGLE PARTICLE
7NSI validation report missing
Macromolecular Entities
Polymer Type:polyribonucleotide
Molecule:12S rRNA
Chain IDs:ZA (auth: AA)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S2, mit
Gene (Uniprot):MRPS2
Chain IDs:EB (auth: AB)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1S001 Pfam ID:PF00318
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S24, mi
Gene (Uniprot):MRPS24
Chain IDs:FB (auth: AC)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A287ANU4 Pfam ID:PF14955
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S5, mit
Gene (Uniprot):MRPS5
Chain IDs:GB (auth: AE)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1SU66 Pfam ID:PF00333, PF03719, PF21251
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Chain IDs:HB (auth: AF)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S7, mit
Gene (Uniprot):MRPS7
Chain IDs:IB (auth: AG)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A286ZJ25 Pfam ID:PF00177
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S9, mit
Gene (Uniprot):MRPS9
Chain IDs:JB (auth: AI)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:I3LU08 Pfam ID:PF00380
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S10, mi
Gene (Uniprot):MRPS10
Chain IDs:KB (auth: AJ)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1RUU2 Pfam ID:PF00338
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS11
Chain IDs:LB (auth: AK)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A286ZJJ6 Pfam ID:PF00411
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitoribosomal protein us12m,
Chain IDs:MB (auth: AL)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A0M3KL52 Pfam ID:PF00164
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S14, mi
Gene (Uniprot):MRPS14
Chain IDs:NB (auth: AN)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A0M3KL53 Pfam ID:PF00253
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S15, mi
Gene (Uniprot):MRPS15
Chain IDs:OB (auth: AO)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A4X1VVY1 Pfam ID:PF00312
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S16, mi
Chain IDs:PB (auth: AP)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A480JTD7 Pfam ID:PF00886
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:uS17m
Chain IDs:QB (auth: AQ)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A8D1UDM1 Pfam ID:PF00366
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S18c, m
Gene (Uniprot):MRPS18C
Chain IDs:RB (auth: AR)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A0M3KL54 Pfam ID:PF01084
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S21, mi
Gene (Uniprot):MRPS21
Chain IDs:SB (auth: AU)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A286ZNB3 Pfam ID:PF01165
Polymer Type:polyribonucleotide
Molecule:tRNA (P/E)
Chain IDs:BB (auth: AV)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
Polymer Type:polyribonucleotide
Molecule:mRNA
Chain IDs:CB (auth: AX)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
Polymer Type:polypeptide(L)
Molecule:unknown
Chain IDs:TB (auth: AZ)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS22
Chain IDs:UB (auth: Aa)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A287AQT5 Pfam ID:PF10245
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Chain IDs:VB (auth: Ab)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Interferon alpha-inducible pr
Gene (Uniprot):MRPS25
Chain IDs:WB (auth: Ac)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A0M3KL55 Pfam ID:PF05047
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S26, mi
Gene (Uniprot):MRPS26
Chain IDs:XB (auth: Ad)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1S8A5 Pfam ID:PF14943
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS27
Chain IDs:YB (auth: Ae)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A5G2R5D6 Pfam ID:PF10037
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S28, mi
Gene (Uniprot):MRPS28
Chain IDs:ZB (auth: Af)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A0M3KL56 Pfam ID:PF10246
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Death associated protein 3
Chain IDs:AC (auth: Ag)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A8D1XNL0 Pfam ID:PF10236
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S31, mi
Gene (Uniprot):MRPS31
Chain IDs:BC (auth: Ah)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A4X1SQW0 Pfam ID:PF15433
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Chain IDs:CC (auth: Ai)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A4X1V2H3 Pfam ID:PF08293
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS34
Chain IDs:DC (auth: Aj)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A287AVS9 Pfam ID:PF16053
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S35, mi
Gene (Uniprot):MRPS35
Chain IDs:EC (auth: Ak)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1SG95 Pfam ID:PF10213
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Coiled-coil-helix-coiled-coil
Chain IDs:FC (auth: Am)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A4X1SZV4 Pfam ID:PF06747
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Aurora kinase A interacting p
Chain IDs:GC (auth: An)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A8D2A802 Pfam ID:PF08213
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Pentatricopeptide repeat doma
Gene (Uniprot):PTCD3
Chain IDs:HC (auth: Ao)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1SVC4 Pfam ID:PF22330, PF13812
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:28S ribosomal protein S18b, m
Gene (Uniprot):MRPS18B
Chain IDs:IC (auth: Ap)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:Q767K8 Pfam ID:PF01084
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L27, mi
Chain IDs:A (auth: B0)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A4X1U0F6 Pfam ID:PF01016
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L28, mi
Gene (Uniprot):MRPL28
Chain IDs:B (auth: B1)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A286ZTW8 Pfam ID:PF00830
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL47
Chain IDs:C (auth: B2)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1SGC7 Pfam ID:PF06984
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L30, mi
Chain IDs:D (auth: B3)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A8D1MIP3 Pfam ID:PF00327
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Chain IDs:E (auth: B4)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A4X1ULI6 Pfam ID:PF09776
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:bL32m
Gene (Uniprot):MRPL32
Chain IDs:F (auth: B5)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:I3LTC4 Pfam ID:PF01783
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L33, mi
Chain IDs:G (auth: B6)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A4X1TLP9 Pfam ID:PF00471
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L34, mi
Chain IDs:I (auth: B7)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A4X1UFR4 Pfam ID:PF00468
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L35, mi
Gene (Uniprot):MRPL35
Chain IDs:JA (auth: B8)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1SVC5
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal protein
Chain IDs:AB (auth: B9)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A4X1THS9 Pfam ID:PF00444
Polymer Type:polyribonucleotide
Molecule:16S rRNA
Chain IDs:DB (auth: BA)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
Polymer Type:polyribonucleotide
Molecule:CP tRNAPhe
Chain IDs:H (auth: BB)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosomal_L2_C domain-contain
Gene (Uniprot):MRPL2
Chain IDs:J (auth: BD)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A287A143 Pfam ID:PF00181, PF03947
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:ICT1
Gene (Uniprot):MRPL3
Chain IDs:K (auth: BE)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A140UHW4 Pfam ID:PF00297
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL4
Chain IDs:L (auth: BF)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A287B2W3 Pfam ID:PF00573
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Ribosome-recycling factor, mi
Gene (Uniprot):MRRF
Chain IDs:M (auth: BG)
Chain Length:0
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:Q96E11 Pfam ID:PF01765
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L9, mit
Gene (Uniprot):MRPL9
Chain IDs:N (auth: BI)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:I3LR45 Pfam ID:PF01281, PF22078, PF25131
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L10, mi
Gene (Uniprot):MRPL10
Chain IDs:O (auth: BJ)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A480VPY3 Pfam ID:PF00466
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L11, mi
Chain IDs:P (auth: BK)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A480KRD0 Pfam ID:PF03946, PF00298
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L13, mi
Gene (Uniprot):MRPL13
Chain IDs:Q (auth: BN)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:K7GP19 Pfam ID:PF00572
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:uL14m
Gene (Uniprot):MRPL14
Chain IDs:R (auth: BO)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A4X1V5Y7 Pfam ID:PF00238
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L15, mi
Chain IDs:S (auth: BP)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A8D0HMG9 Pfam ID:PF00828
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L16, mi
Chain IDs:T (auth: BQ)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A480MAF3 Pfam ID:PF00252
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L17, mi
Gene (Uniprot):MRPL17
Chain IDs:U (auth: BR)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1RMQ4 Pfam ID:PF01196
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L18, mi
Gene (Uniprot):MRPL18
Chain IDs:V (auth: BS)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A0R4J8D5 Pfam ID:PF00861
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L19, mi
Gene (Uniprot):MRPL19
Chain IDs:W (auth: BT)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:I3LNJ0 Pfam ID:PF01245
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L20, mi
Gene (Uniprot):MRPL20
Chain IDs:X (auth: BU)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A286ZU56 Pfam ID:PF00453
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L21, mi
Chain IDs:Y (auth: BV)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1RY70 Pfam ID:PF00829
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L22, mi
Chain IDs:Z (auth: BW)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A4X1TXR4 Pfam ID:PF00237
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L23, mi
Gene (Uniprot):MRPL23
Chain IDs:AA (auth: BX)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A480JJI1 Pfam ID:PF00276
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L24, mi
Gene (Uniprot):MRPL24
Chain IDs:BA (auth: BY)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1RHJ1 Pfam ID:PF00467, PF17136
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L37, mi
Gene (Uniprot):MRPL37
Chain IDs:CA (auth: Ba)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A287BIV6 Pfam ID:PF07147
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L38, mi
Gene (Uniprot):MRPL38
Chain IDs:DA (auth: Bb)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1RW03 Pfam ID:PF01161
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:TGS domain-containing protein
Chain IDs:EA (auth: Bc)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A4X1UDR3
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL40
Chain IDs:FA (auth: Bd)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A5G2R2V2 Pfam ID:PF09812
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Chain IDs:GA (auth: Be)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A8D1F1K9 Pfam ID:PF09809
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:mL42
Gene (Uniprot):MRPL42
Chain IDs:HA (auth: Bf)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A287BQA1 Pfam ID:PF10210
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L43, mi
Gene (Uniprot):MRPL43
Chain IDs:IA (auth: Bg)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1S8U4 Pfam ID:PF05047
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L44, mi
Gene (Uniprot):MRPL44
Chain IDs:KA (auth: Bh)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1SR64 Pfam ID:PF22935, PF22892
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL45
Chain IDs:LA (auth: Bi)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:I3LGM5 Pfam ID:PF04280
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L46, mi
Gene (Uniprot):MRPL46
Chain IDs:MA (auth: Bj)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1SRT0 Pfam ID:PF11788
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L48, mi
Gene (Uniprot):MRPL48
Chain IDs:NA (auth: Bk)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A480J9Z6 Pfam ID:PF00338
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L49, mi
Gene (Uniprot):MRPL49
Chain IDs:OA (auth: Bl)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A4X1V1G7 Pfam ID:PF05046
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L50, mi
Gene (Uniprot):MRPL50
Chain IDs:PA (auth: Bm)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:I3L9H6 Pfam ID:PF10501
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L51, mi
Chain IDs:QA (auth: Bn)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A8D1P1C8 Pfam ID:PF10244
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L52, mi
Gene (Uniprot):MRPL52
Chain IDs:RA (auth: Bo)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:F1S9B7 Pfam ID:PF18699
Polymer Type:polypeptide(L)
Molecule:mL53
Chain IDs:SA (auth: Bp)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L54, mi
Chain IDs:TA (auth: Bq)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A480PHA9 Pfam ID:PF08561
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL57
Chain IDs:UA (auth: Bt)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A287BP93 Pfam ID:PF14978
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPL58
Chain IDs:VA (auth: Bu)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A286ZJR2 Pfam ID:PF00472
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein L59, mi
Gene (Uniprot):GADD45GIP1
Chain IDs:WA (auth: Bv)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A286ZXA6 Pfam ID:PF10147
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:39S ribosomal protein S30, mi
Gene (Uniprot):MRPS30
Chain IDs:XA (auth: Bw)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A480QIM3 Pfam ID:PF07147
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Gene (Uniprot):MRPS18A
Chain IDs:YA (auth: Bx)
Chain Length:0
Number of Molecules:1
Biological Source:Sus scrofa
UniProt ID:A0A5G2R1G5 Pfam ID:PF01084
Structures with similar UniProt ID
Structural Superimposition Protein Blast
Polymer Type:polypeptide(L)
Molecule:Mitochondrial ribosomal prote
Chain IDs:JC (auth: CL), KC (auth: DL), LC (auth: EL), MC (auth: FL), NC (auth: GL), OC (auth: HL)
Chain Length:0
Number of Molecules:6
Biological Source:Sus scrofa
UniProt ID:A0A4X1U6S6 Pfam ID:PF16320, PF00542
Ligand Molecules
5GP
GTP
MG
SPM
ZN
Primary Citation
Structural basis of translation termination, rescue, and recycling in mammalian mitochondria.
Mol.Cell 81 2566 2582.e6 (2021)
PMID: 33878294 DOI: 10.1016/j.molcel.2021.03.042

Abstact

The mitochondrial translation system originates from a bacterial ancestor but has substantially diverged in the course of evolution. Here, we use single-particle cryo-electron microscopy (cryo-EM) as a screening tool to identify mitochondrial translation termination mechanisms and to describe them in molecular detail. We show how mitochondrial release factor 1a releases the nascent chain from the ribosome when it encounters the canonical stop codons UAA and UAG. Furthermore, we define how the peptidyl-tRNA hydrolase ICT1 acts as a rescue factor on mitoribosomes that have stalled on truncated messages to recover them for protein synthesis. Finally, we present structural models detailing the process of mitochondrial ribosome recycling to explain how a dedicated elongation factor, mitochondrial EFG2 (mtEFG2), has specialized for cooperation with the mitochondrial ribosome recycling factor to dissociate the mitoribosomal subunits at the end of the translation process.

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Primary Citation of related structures
7NSI
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