ISDA: 7MEJ

Deposition Date 2021-04-06

Release Date 2021-08-11

Last Version Date 2025-05-14

Entry Detail

PDB ID:

7MEJ

Keywords:

VIRAL PROTEIN/Immune System

Title:

CryoEM structure of SARS-CoV-2 RBD in complex with nanobodies Nb21 and Nb36

Biological Source:

Source Organism(s):

Lama glama (Taxon ID: 9844)
Severe acute respiratory syndrome coronavirus 2 (Taxon ID: 2697049)

Expression System(s):

Escherichia coli 'bl21-gold(de3)plyss ag', Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.55 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Polymer Type:polypeptide(L)
Molecule:Nanobody Nb21
Chain IDs:A
Chain Length:117
Number of Molecules:1
Biological Source:Lama glama

Polymer Type:polypeptide(L)
Molecule:Nanobody Nb36
Chain IDs:C (auth: B)
Chain Length:123
Number of Molecules:1
Biological Source:Lama glama

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Spike protein S1
Gene (Uniprot):S
Chain IDs:B (auth: R)
Chain Length:194
Number of Molecules:1
Biological Source:Severe acute respiratory syndrome coronavirus 2

UniProt ID:P0DTC2 Pfam ID:PF09408

Ligand Molecules

Primary Citation

Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes

Sun, D, Sang, Z, Kim, Y.J, Xiang, Y, Cohen, T, Belford, A.K, Huet, A, Conway, J.F, Sun, J, Taylor, D.J, Schneidman-Duhovny, D, Zhang, C, Huang, W, Shi, Y.Show

Nat Commun 12 4676 ? (2021)

DOI: 10.1038/s41467-021-24963-3

Primary Citation of related structures

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