7LL4 image
Deposition Date 2021-02-03
Release Date 2022-01-12
Last Version Date 2024-11-06
Entry Detail
PDB ID:
7LL4
Keywords:
TRANSFERASE
Title:
High-resolution crystal structure of human JAK2 kinase domain (JH1) bound to PN5-114.
Biological Source:
Source Organism(s):
Homo sapiens (Taxon ID: 9606)
Expression System(s):
Mammalian expression vector flag-mcs-pcdna3.1
Method Details:
Experimental Method:
X-RAY DIFFRACTION
Resolution:
1.31 Å
R-Value Free:
0.19
R-Value Work:
0.17
R-Value Observed:
0.17
Space Group:
C 1 2 1
7LL4 validation report missing
Macromolecular Entities
Structures with similar UniProt ID
Protein Blast
Polymer Type:polypeptide(L)
Molecule:Tyrosine-protein kinase JAK2
Gene (Uniprot):JAK2
Chain IDs:A
Chain Length:297
Number of Molecules:1
Biological Source:Homo sapiens
UniProt ID:O60674 Pfam ID:PF07714 EC:2.7.10.2
Modified Residue
Compound ID Chain ID Parent Comp ID Details 2D Image
PTR A TYR modified residue
Ligand Molecules
Y5D
Primary Citation
High-resolution crystal structure of human Janus Kinase 2 kinase domain (JH1) bound to PN5-114.
To be published ? ? ? (?)
Primary Citation of related structures
7LL4
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