ISDA: 7I93

Deposition Date 2025-03-24

Release Date 2026-05-20

Last Version Date 2026-05-20

Entry Detail

PDB ID:

7I93

Keywords:

HYDROLASE

Title:

Crystal Structure of 27 bound to the PH domain of Btk

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli bl21(de3)

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.91 Å

R-Value Free:

0.31

R-Value Work:

0.25

R-Value Observed:

0.26

Space Group:

P 1 21 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Tyrosine-protein kinase BTK
Gene (Uniprot):BTK
Mutagens:C145S
Chain IDs:A, B, C, D
Chain Length:169
Number of Molecules:4
Biological Source:Homo sapiens

UniProt ID:Q06187 Pfam ID:PF00169, PF00779 EC:2.7.10.2

Ligand Molecules

A1B6U

Primary Citation

Inhibition of a Pleckstrin Homology Domain by Lysine-reactive Covalent Inhibitor

Brear, P, West, R.M, Nicolescu, R.C.B, Blaszczyk, B.K, Anwar, A, Deingruber, T, Sanders, M.G, Perez-Areales, F.J, Stephens, L.R, Hawkins, P.T, Spring, D.R, Hyvonen, M.Show

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Primary Citation of related structures

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