ISDA: 7EKT

Deposition Date 2021-04-06

Release Date 2021-05-19

Last Version Date 2024-11-20

Entry Detail

PDB ID:

7EKT

Keywords:

MEMBRANE PROTEIN

Title:

human alpha 7 nicotinic acetylcholine receptor bound to EVP-6124 and PNU-120596

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Homo sapiens

Method Details:

Experimental Method:

ELECTRON MICROSCOPY

Resolution:

3.02 Å

Aggregation State:

PARTICLE

Reconstruction Method:

SINGLE PARTICLE

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Neuronal acetylcholine recept
Gene (Uniprot):CHRNA7
Chain IDs:A, B, C, D, E
Chain Length:502
Number of Molecules:5
Biological Source:Homo sapiens

UniProt ID:P36544 Pfam ID:PF02931, PF02932

Ligand Molecules

CLR

I33

I34

NAG

Primary Citation

Structural basis of human alpha 7 nicotinic acetylcholine receptor activation.

Zhao, Y, Liu, S, Zhou, Y, Zhang, M, Chen, H, Eric Xu, H, Sun, D, Liu, L, Tian, C.Show

Cell Res. 31 713 716 (2021)

PMID: 33958730 DOI: 10.1038/s41422-021-00509-6

Primary Citation of related structures

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