ISDA: 7DPO

Deposition Date 2020-12-21

Release Date 2021-12-22

Last Version Date 2023-11-29

Entry Detail

PDB ID:

7DPO

Keywords:

ANTITUMOR PROTEIN

Title:

Crystal Structure of BRD2(BD2)with Ligand ZB-BD-224 bound

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

2.30 Å

R-Value Free:

0.24

R-Value Work:

0.20

R-Value Observed:

0.20

Space Group:

C 1 2 1

Download Validation Report

Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Bromodomain-containing protei
Gene (Uniprot):BRD2
Chain IDs:A
Chain Length:112
Number of Molecules:1
Biological Source:Homo sapiens

UniProt ID:P25440 Pfam ID:PF00439

Ligand Molecules

HFU

Primary Citation

Structure Base Design of A new chemotype of Four-Cycle Compounds as Bromodomain and Extra-Terminal (BET) Inhibitors with The Second Bromodomain Bias and Highly Anti-inflammatory Potency

Li, Z, Lu, T, Chen, P, Luo, C, Zgou, B.Show

To be published ? ? ? (?)

Primary Citation of related structures

Feedback Form