ISDA: 7DPN

Deposition Date 2020-12-20

Release Date 2021-12-22

Last Version Date 2023-11-29

Entry Detail

PDB ID:

7DPN

Keywords:

ANTITUMOR PROTEIN

Title:

Crystal structure of BRD2(BD1)with ligand ZB-BD-224 bound

Biological Source:

Source Organism(s):

Homo sapiens (Taxon ID: 9606)

Expression System(s):

Escherichia coli

Method Details:

Experimental Method:

X-RAY DIFFRACTION

Resolution:

1.80 Å

R-Value Free:

0.21

R-Value Work:

0.18

R-Value Observed:

0.18

Space Group:

C 1 2 1

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Macromolecular Entities

Structures with similar UniProt ID

Protein Blast

Polymer Type:polypeptide(L)
Molecule:Bromodomain-containing protei
Gene (Uniprot):BRD2
Chain IDs:A, B, C
Chain Length:122
Number of Molecules:3
Biological Source:Homo sapiens

UniProt ID:P25440 Pfam ID:PF00439

Ligand Molecules

HFU

Primary Citation

Structure Base Design of A new chemotype of Four-Cycle Compounds as Bromodomain and Extra-Terminal (BET) Inhibitors with The Second Bromodomain Bias and Highly Anti-inflammatory Potency

Li, Z, Lu, T, Chen, P, Luo, C, Zgou, B.Show

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Primary Citation of related structures

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